06 October 2020 : Database Analysis
Creation of a Prognostic Risk Prediction Model for Lung Adenocarcinoma Based on Gene Expression, Methylation, and Clinical Characteristics
Honggang Ke1CD, Yunyu Wu2DEF, Runjie Wang3CDF, Xiaohong Wu4AB*DOI: 10.12659/MSM.925833
Med Sci Monit 2020; 26:e925833
Table 6 Univariate and multivariate Cox regression analyses of clinical factors.
| Clinical characteristics | Univariate Cox regression | Multivariate Cox regression | ||
|---|---|---|---|---|
| P value | HR (95%CI) | P value | HR (95%CI) | |
| Age (above/below median, 65 years) | 0.4370 | 1.155 (0.804~1.659) | – | – |
| Sex (Male/Female) | 0.7450 | 1.062 (0.741~1.52) | – | – |
| Pathologic M (M0/M1) | 0.1310 | 1.692 (0.848~3.378) | – | – |
| Targeted molecular therapy (yes/no) | 0.1601 | 1.366 (0.883~ 2.114) | – | v |
| Tobacco smoking history (current/reformed/never) | 0.9900 | 1.002 (0.737~1.362) | – | – |
| Radiation therapy (yes/no) | 0.0035 | 2.033 (1.25~3.307) | 0.5924 | 1.163 (0.669~2.019) |
| Pathologic N (N0/N1/N2) | <0.0001 | 1.85 (1.494~2.29) | 0.0471 | 1.439 (1.005~2.060) |
| Pathologic T (T1/T2/T3/T4) | 0.0002 | 1.537 (1.223~1.932) | 0.0169 | 1.236 (0.914~1.672) |
| Pathologic stage (I/II/III/IV) | <0.0001 | 1.671 (1.413~1.976) | 0.0103 | 1.279 (0.952~1.718) |
| New tumor (yes/no) | <0.0001 | 2.362 (1.535~3.634) | 0.0001 | 2.395 (1.533~3.742) |
| HR – hazard ratio. | ||||