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25 September 2020: Clinical Research

Clinical Characteristics and Risk Factors of Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Patients in Beijing, China: A Retrospective Study

Aibin Wang 1ABCDE* , Guiju Gao 1ABE* , Sa Wang 1ABDEF* , Meiling Chen 2C* , Fang Qian 1B , Weiming Tang 3BD , Yanli Xu 1B , Rui Song 1B , Liwei Zhuang 4B , Xiaoyang Ma 5B , Tianwei Zhao 1B , Xiaodi Guo 4B , Wei Li 4B , Xudong Wang 6B , Baoliang Li 6B , Chun Hu 6B , Zhihai Chen 1ADE* , Fujie Zhang 1ADE*

DOI: 10.12659/MSM.925974

Med Sci Monit 2020; 26:e925974

Table 3 Laboratory and radiologic findings of COVID cases in Beijing, China.

Clinical characteristicsAll patients (n=130)Non-ARDS (n=104)ARDS (n=26)P
WBC, Median (range) – 10/L4.45 (3.50–5.49)4.45 (3.55–5.19)4.40 (3.19–6.10)0.662
51/129 (39.53)39/103 (37.86)12/26 (46.15)0.440
Lym count, Median (range) – 10/L1.07 (0.72–1.50)1.18 (0.94–1.57)0.60 (0.42–0.77)0.000
 >1.0×10/L, No. (%)76/129 (58.91)73/103 (70.87)3/26 (11.54)
 0.5–1.0×10/L, No. (%)41/129 (31.78)28/103 (27.18)13/26 (50.00)0.000
12/129 (9.30)2/103 (0.99)10/26 (38.46)
Ccr, Median (range) – ml/min112.2 (82.2–135.2)116.6 (84.5–137.2)107.1 (71.4–120.1)0.092
43/126 (34.1)33/102 (32.4)10/24 (41.7)0.388
Cr, Median (range) – umol/l68.5 (55.85–82.10)68.00 (55.80–80.70)69.55 (55.60–88.45)0.557
 >104 umol/l, No. (%)5/129 (3.88)5/103 (4.85)00.564
ALT, Median (range) – u/l25.80 (18.45–37.95)24.80 (17.20–36.70)34.5 (21.48–54.68)0.020
 >40 u/l, No. (%)29/129 (22.48)18/103 (17.47)10/26 (38.46)0.020
LDH, Median (range) – u/l227 (189–310)218 (188–283)305 (195–373)0.026
 >250 u/l, No. (%)49/117 (41.88)34/92 (36.96)15/25 (60.00)0.058
CK, Median (range) – u/l66.90 (46.20–105.90)66.00 (48.40–103.00)71.10 (29.35–190.50)0.842
 >198 u/l, No. (%)12/129 (10.26)6/103 (9.09)6/26 (11.54)0.020
CK-MB, Median (range) – u/l16.00 (13.00–21.3)15.50 (12.90–18.80)15.90 (13.20–22.80)0.309
 >25 u/l, No. (%)9/126 (7.14)4/91 (4.40)5/25 (20.00)0.021
CRP, Median (range) – mg/dl23.70 (5.00–53.10)15.40 (4.30–34.00)102.00 (45.50–120.63)0.000
 >5 mg/dl, No. (%)96/129 (74.42)71/103 (68.93%)25/26 (96.15%)0.004
PT, Median (range) – s12.30 (11.70–13.40)12.10 (11.60–13. 25)13.15 (12.50–13.60)0.001
 >12.5 s, No. (%)57/127 (44.88)38/101 (37.62)19/26 (73.08)0.001
FIB, Median (range) – mg/dl343.00 (230.00–405.00)327 (221–387)415 (305–468)0.000
 >400 mg/dl, No. (%)33/127 (25.98)19/101 (18.81)14/26 (53.85)0.000
Lung inflammation No. (%)125 (96.15)99 (96.12)26 (100)0.698
Bilateral lung inflammation No. (%)71 (54.62)45 (43.27)26 (100)0.000
CD4+T lymphocyte count, Median (range) – cells/ul537 (384–713.5)537 (404–717)471 (273–705)0.000
64/89 (71.91)49/69 (71.01)15/20 (75.00)0.727
CD8+T lymphocyte count, Median (range) – cells/ul331 (187.5–576)409 (257–624)170 (127–273)0.192
41/89 (46.07)24/69 (34.78)17/20 (85.00)0.000

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750