Sodium-Glucose Cotransporter-2 Inhibitor Immediately Decreases Serum Uric Acid Levels in Type 2 Diabetic Patients

Naro Ohashi; Taro Aoki; Takashi Matsuyama; Sayaka Ishigaki; Shinsuke Isobe; Tomoyuki Fujikura; Takuya Hashimoto; Daisuke Tsuriya; Hiroshi Morita; Akihiko Kato; Hideo Yasuda

doi:10.12659/MSM.926086

02 October 2020 : Clinical Research

Sodium-Glucose Cotransporter-2 Inhibitor Immediately Decreases Serum Uric Acid Levels in Type 2 Diabetic Patients

Naro Ohashi^1ABCDEF*, Taro Aoki^1BCE, Takashi Matsuyama^1BCE, Sayaka Ishigaki^2BCE, Shinsuke Isobe^1BCE, Tomoyuki Fujikura^1A, Takuya Hashimoto^3ABDE, Daisuke Tsuriya^3ABDE, Hiroshi Morita^3ABDE, Akihiko Kato^2AD, Hideo Yasuda^1ACDE

DOI: 10.12659/MSM.926086

Med Sci Monit 2020; 26:e926086

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Table 5 Multiple linear regression analyses of the percentage changes in serum uric acid levels from baseline to 6 months after sodium-glucose cotransporter-2 inhibitor administration.

	Model 1		Model 2		Model 3		Model 4
	R=0.39	p=0.48	R=0.40	p=0.66	R=0.63	p=0.015	R=0.65	p=0.035
	β	p	β	p	β	p	β	p
Age (year)	−0.37	0.15	−0.36	0.19	−0.43	0.023	−0.43	0.030
Sex	−0.082	0.75	−0.067	0.82	−0.030	0.87	−0.031	0.88
Change of BMI (%)			0.079	0.78			0.069	0.73
Change of FE (%)	0.066	0.80	0.065	0.81
Change of sCr (%)					0.41	0.038	0.42	0.041
BMI – body mass index, FE – fractional excretion of uric acid, sCr – serum creatinine.

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Sodium-Glucose Cotransporter-2 Inhibitor Immediately Decreases Serum Uric Acid Levels in Type 2 Diabetic Patients

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