27 October 2020 : Clinical Research
Stroke Incidence in Survivors of Carbon Monoxide Poisoning in South Korea: A Population-Based Longitudinal Study
Hyuk-Hoon Kim1ABCE, Sangchun Choi1ADEF*, Yoon Seok Jung1CD, Young-Gi Min1AC, Dukyong Yoon2BC, Sung Eun Lee1DFDOI: 10.12659/MSM.926116
Med Sci Monit 2020; 26:e926116
Table 2 Serial annual incidence rate of stroke types after carbon monoxide (CO) poisoning.
| Time after CO poisoning | Total stroke (I60–64) | Ischemic stroke (I63) | Hemorrhagic stroke (I60–62) | Intracranial hemorrhage (I61) | Subarachnoid hemorrhage (I60) | |
|---|---|---|---|---|---|---|
| First year | Obs. (Exp.) | 582 (29.89) | 494 (20.60) | 88 (8.80) | 59 (5.08) | 20 (3.03) |
| SIR (95% CI) | 19.47 (17.92–21.12) | 23.99 (21.92–26.20) | 10.05 (8.06–12.39) | 11.62 (8.84–14.99) | 6.60 (4.03–10.20) | |
| First quarter | Obs. (Exp.) | 427 (7.47) | 371 (5.27) | 56 (2.34) | 40 (1.17) | 11 (0.88) |
| SIR (95% CI) | 57.14 (51.86–62.84) | 70.34 (63.37–77.88) | 23.89 (18.05–31.02) | 34.13 (24.38–46.47) | 12.51 (6.24–22.39) | |
| Second quarter | Obs. (Exp.) | 72 (7.26) | 61 (5.14) | 11 (2.31) | 6 (1.15) | 3 (0.87)* |
| SIR (95% CI) | 9.92 (7.76–12.49) | 11.87 (9.08–15.25) | 4.77 (2.38–8.53) | 5.20 (1.90–11.32) | 3.46 (0.70–10.12) | |
| Third quarter | Obs. (Exp.) | 42 (6.99) | 34 (4.95) | 8 (2.23) | 4 (1.1)* | 4 (0.84)* |
| SIR (95% CI) | 6.00 (4.33–8.12) | 6.87 (4.76–9.60) | 3.59 (1.55–7.08) | 3.59 (0.97–9.19) | 4.78 (1.28–12.24) | |
| Fourth quarter | Obs. (Exp.) | 41 (6.66) | 28 (4.72) | 13 (2.12) | 9 (1.06) | 3 (0.80)* |
| SIR (95% CI) | 6.15 (4.41–8.35) | 7.21 (4.99–10.07) | 6.12 (3.25–10.46) | 8.46 (3.86–16.07) | 3.75 (0.76–10.98) | |
| Second year | Obs. (Exp.) | 140 (24.82) | 107 (17.32) | 33 (7.46) | 19 (4.29) | 14 (2.57) |
| SIR (95% CI) | 5.64 (4.75–6.66) | 6.18 (5.06–7.47) | 4.42 (3.04–6.21) | 4.37 (2.62–6.85) | 5.59 (3.08–9.33) | |
| Third year | Obs. (Exp.) | 98 (20.07) | 79 (14.02) | 19 (6.06) | 16 (3.49) | 3 (2.09)* |
| SIR (95% CI) | 4.88 (3.96–5.95) | 5.63 (4.46–7.02) | 3.14 (1.89–4.90) | 4.52 (2.57–7.37) | 1.62 (0.37–4.48) | |
| Fourth year | Obs. (Exp.) | 82 (15.41) | 65 (10.78) | 17 (4.70) | 14 (2.69) | 2 (1.61)* |
| SIR (95% CI) | 5.32 (4.23–6.60) | 6.03 (4.65–7.69) | 3.64 (2.12–5.82) | 5.20 (2.84–8.73) | 1.24 (0.14–4.49) | |
| Fifth year | Obs. (Exp.) | 50 (10.85) | 40 (7.60) | 10 (3.30) | 3 (1.90)* | 3 (1.14)* |
| SIR (95% CI) | 4.61 (3.42–6.07) | 5.26 (3.76–7.17) | 3.03 (1.45–5.57) | 1.31 (0.20–4.20) | 2.19 (0.35–7.02) | |
| Sixth year | Obs. (Exp.) | 26 (6.32) | 22 (4.43) | 4 (1.94)* | 3 (1.12)* | 1 (0.67)* |
| SIR (95% CI) | 4.11 (2.69–6.03) | 4.97 (3.11–7.52) | 2.07 (0.56–5.29) | 2.48 (0.45–7.54) | 1.50 (0.02–8.33) | |
| Seventh year | Obs. (Exp.) | 6 (2.63) | 6 (1.85) | 0 (0.81) | 0 (0.28) | 0 (0.47) |
| SIR (95% CI) | 2.28 (0.83–4.96) | 3.25 (1.19–7.07) | – | – | – | |
| CO – carbon monoxide; Obs – observed; Exp – expected; SIR – standardized incidence rate; CI – confidence interval. * Exact confidence interval calculated using mid- exact test. | ||||||