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27 September 2020: Database Analysis

A Network Pharmacological Approach to Investigate the Mechanism of Action of Active Ingredients of and Their Potential Targets in Treatment of Alzheimer’s Disease

Yajuan Li ABCDEF , Qin Yang BF , Yang Yu AG*

DOI: 10.12659/MSM.926295

Med Sci Monit 2020; 26:e926295

Table 2 KEGG signal pathway information.

TermCountPercentage (%)P valueGenes
HIF-1 signaling pathway933.3310MAPK1, TF, IL6, HMOX1, BCL2, VEGFA, NOS3, NOS2, INSR
TNF signaling pathway622.223.44×10MAPK1, IL6, TNF, CCL2, PTGS2, IL1B
Serotonergic synapse622.224.11×10MAPK1, APP, PTGS2, SLC6A4, PTGS1, MAOB
NOD-like receptor signaling pathway518.524.39×10MAPK1, IL6, TNF, CCL2, IL1B
Prion diseases414.812.36×10MAPK1, IL6, IL1B, SOD1
Rheumatoid arthritis518.522.58×10IL6, TNF, CCL2, VEGFA, IL1B
Influenza A622.223.44×10MAPK1, IL6, TNF, CCL2, GSK3B, IL1B
Pathways in cancer829.633.69×10MAPK1, IL6, PTGS2, GSK3B, BCL2, VEGFA, PPARG, NOS2
Insulin resistance518.525.64×10IL6, TNF, GSK3B, NOS3, INSR
Malaria414.816.99×10IL6, TNF, CCL2, IL1B
Sphingolipid signaling pathway518.528.39×10MAPK1, TNF, BCL2, CTSD, NOS3
PI3K-Akt signaling pathway725.931.2×10MAPK1, IL6, GSK3B, BCL2, VEGFA, NOS3, INSR
VEGF signaling pathway414.811.33×10MAPK1, PTGS2, VEGFA, NOS3
Non-alcoholic fatty liver disease (NAFLD)518.521.97×10IL6, TNF, GSK3B, IL1B, INSR
Alzheimer’s disease518.522.91×10MAPK1, APP, TNF, GSK3B, IL1B
Salmonella infection414.813.22×10MAPK1, IL6, IL1B, NOS2
NF-kappa B signaling pathway414.813.68×10TNF, PTGS2, BCL2, IL1B
Graft-versus-host disease311.116.25×10IL6, TNF, IL1B
Toll-like receptor signaling pathway414.816.39×10MAPK1, IL6, TNF, IL1B
Amoebiasis414.816.39×10IL6, TNF, IL1B, NOS2

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750