10 October 2020 : Clinical Research
A Nomogram for Prediction of Survival in Patients After Gastrectomy Within Enhanced Recovery After Surgery (ERAS): A Single-Center Retrospective Study
Yuqi Sun1DE, Zequn Li1A, Xiaodong Liu1AF, Shougen Cao1CD, Xuechao Liu1C, Chuan Hu2F, Yulong Tian1AD, Jianfei Xu1E, Daoshen Wang1G, Xin Zhou1F, Yanbing Zhou1AG*DOI: 10.12659/MSM.926347
Med Sci Monit 2020; 26:e926347
Table 3 Univariate and multivariate Cox proportional hazard analyses of OS with GC patients.
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Sex (Male vs. Female) | 0.822 (0.554–1.221) | 0.333 | ||
| Age | 2.044 (1.411–2.961) | <0.001 | 1.802 (1.199–2.710) | 0.005 |
| BMI | 0.681 (0.456–1.016) | 0.060 | ||
| ASA classification | 0.562 | |||
| I | Reference | |||
| II | 1.149 (0.466–2.831) | 0.763 | ||
| III | 1.389 (0.547–3.527) | 0.489 | ||
| Comorbidity | 1.100 (0.773–1.566) | 0.597 | ||
| Tumor size | <0.001 | 0.958 | ||
| ≤3 | Reference | Reference | ||
| 3–5 | 2.462 (1.494–4.055) | <0.001 | 0.956 (0.557–1.642) | 0.871 |
| >5 | 4.233 (2.684–6.675) | <0.001 | 0.924 (0.539–1.582) | 0.772 |
| Tumor location | <0.001 | 0.130 | ||
| Cardia/fundus | Reference | Reference | ||
| Body | 0.499 (0.283–0.878) | 0.016 | 0.552 (0.301–1.011) | 0.054 |
| Antrum/pylorus | 0.376 (0.238–0.594) | <0.001 | 0.652 (0.396–1.075) | 0.094 |
| Tumor differentiation | 0.033 | 0.981 | ||
| Well | Reference | |||
| Moderate | 5.205 (0.684–39.585) | 0.111 | 1.148 (0.135–9.773) | 0.900 |
| Poor | 8.237 (1.150–58.988) | 0.036 | 1.091 (0.133–8.961) | 0.936 |
| Borrmann type | <0.001 | 0.150 | ||
| I | Reference | Reference | ||
| II | 1.209 (0.483–3.030) | 0.685 | 0.464 (0.174–1.233) | 0.124 |
| III | 3.030 (1.335–6.968) | 0.008 | 0.780 (0.319–1.905) | 0.585 |
| IV | 7.509 (2.814–20.036) | <0.001 | 0.985 (0.326–2.981) | 0.979 |
| Intraoperative blood transfusion | 1.840 (1.056–3.205) | 0.031 | 1.598 (0.882–2.895) | 0.122 |
| Surgical approach (laparoscopic open) | 1.633 (0.826–3.229) | 0.159 | ||
| Gastrectomy type (subtotal total gastrectomy) | 2.291 (1.447–3.626) | <0.001 | 1.000 (0.600–1.664) | 0.999 |
| Extent of LN dissection (D2 D2+) | 0.963 (0.660–1.404) | 0.844 | ||
| Depth of invasion | <0.001 | 0.001 | ||
| T1 | Reference | Reference | ||
| T2 | 2.747 (0.804–9.386) | 0.107 | 3.150 (0.791–12.543) | 0.104 |
| T3 | 8.373 (3.001–23.364) | <0.001 | 10.323 (1.624–65.630) | 0.013 |
| T4a | 19.150 (6.981–52.535) | <0.001 | 20.236 (2.909–140.750) | 0.002 |
| T4b | 39.875 (12.264–129.649) | <0.001 | 35.632 (4.744–267.653) | 0.001 |
| Depth of invasion | <0.001 | <0.001 | ||
| N0 | Reference | Reference | ||
| N1 | 2.634 (1.382–5.020) | 0.003 | 2.305 (1.117–4.758) | 0.024 |
| N2 | 6.274 (3.622–10.866) | <0.001 | 4.359 (2.057–9.235) | <0.001 |
| N3a | 9.898 (5.726–17.110) | <0.001 | 5.330 (2.497–11.378) | <0.001 |
| N3b | 13.232 (6.375–27.268) | <0.001 | 7.314 (2.822–18.957) | <0.001 |
| Total LN (continuous) | 1.014 (0.999–1.029) | 0.066 | ||
| AJCC pTNM stage | <0.001 | 0.236 | ||
| I | Reference | Reference | ||
| II | 2.271 (0.952–5.413) | 0.064 | 0.269 (0.057–1.275) | 0.098 |
| III | 12.036 (5.864–24.707) | <0.001 | 0.296 (0.046–1.902) | 0.200 |
| Perioperative malnutrition | 1.503 (1.015–2.226) | 0.042 | 1.001 (0.638–1.571) | 0.996 |
| Complications | 1.922 (1.288–2.868) | 0.001 | 1.648 (1.072–2.532) | 0.023 |
| Postoperative chemotherapy | 2.197 (1.537–3.141) | <0.001 | 1.037 (0.691–1.556) | 0.859 |
| HR – hazard ratio; CI – confidence interval. | ||||