14 October 2020: Lab/In Vitro Research
High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance
Shunda Wang 1ABCDEF , Junjie Li 2ABD , Lei You 1AEF , Menghua Dai 1ACEG* , Yupei Zhao 1AEG*DOI: 10.12659/MSM.926432
Med Sci Monit 2020; 26:e926432
Table 1 Relationship between cytoplasmic MUC15 expression and clinicopathological characteristics in pancreatic cancer.
| Variables | n | MUC15 expression | P-value | |
|---|---|---|---|---|
| High | Low | |||
| 0.076 | ||||
| Male | 59 | 31 (52.5%) | 28 (47.5%) | |
| Female | 33 | 11 (33.3%) | 22 (66.7%) | |
| 0.304 | ||||
| ≤60 | 45 | 23 (51.1%) | 22 (48.9%) | |
| >60 | 47 | 19 (40.4%) | 28 (59.6%) | |
| Elevated | 68 | 28 (41.2%) | 40 (58.8%) | |
| Normal | 18 | 13 (72.2%) | 5 (27.8%) | |
| 0.482 | ||||
| ≥4cm | 42 | 21 (50.0%) | 21 (50.0%) | |
| 47 | 20 (42.6%) | 27 (57.4%) | ||
| 0.360 | ||||
| Head | 53 | 22 (41.5%) | 31 (58.5%) | |
| Non-head | 35 | 18 (51.4%) | 17 (48.6%) | |
| 0.857 | ||||
| Well-moderate | 68 | 30 (44.1%) | 38 (55.9%) | |
| Poor | 15 | 7 (46.7%) | 8 (53.3%) | |
| 0.863 | ||||
| Absent | 36 | 16 (44.4%) | 20 (55.6%) | |
| Present | 54 | 25 (46.3%) | 29 (53.7%) | |
| 0.746 | ||||
| Absent | 63 | 28 (44.4%) | 35 (55.6%) | |
| Present | 27 | 13 (48.1%) | 14 (51.9%) | |
| 0.603 | ||||
| Absent | 50 | 24 (48.0%) | 26 (52.0%) | |
| Present | 40 | 17 (42.5%) | 23 (57.5%) | |
| 0.923 | ||||
| I–IIa | 45 | 21 (46.7%) | 24 (53.3%) | |
| ≥IIb | 46 | 21 (45.7%) | 25 (54.3%) | |
| 0.624 | ||||
| T1–2 | 28 | 14 (50.0%) | 14 (50.0%) | |
| >T3 | 63 | 28 (44.4%) | 35 (55.6%) | |
| 0.696 | ||||
| N0 | 50 | 24 (48.0%) | 26 (52.0%) | |
| N1 | 41 | 18 (43.9%) | 23 (56.1%) | |
| P value in bold is statistically significant. Total patient number does not equal 92 in all categories, as patient information was not available for all cases. T – tumor; N – lymph node. | ||||