High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro

14 October 2020: Lab/In Vitro Research

High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance

Shunda Wang ^1ABCDEF , Junjie Li ^2ABD , Lei You ^1AEF , Menghua Dai ^1ACEG* , Yupei Zhao ^1AEG*

DOI: 10.12659/MSM.926432

Med Sci Monit 2020; 26:e926432

Table 3 Univariate and multivariate analyses of prognosis factors in pancreatic cancer patients.

Variables	Univariate analysis			Multivariate analysis
Variables	Overall survival (Median±SE, months)	95% confidence interval	P value	Hazard ratio	95% confidence interval	P value
						0.056
Male	16.6±1.20	14.295–18.999		0.772	0.342–1.276
Female	23.09±2.46	18.285–27.914		1
			0.343
≤60	19.56±1.74	16.143–22.980
>60	17.80±1.48	14.889–20.723
			0.581
Elevated	18.66±1.37	15.965–21.354
Normal	20.03±2.76	14.616–25.453
						0.969
≥4	16.01±1.23	13.591±18.448		0.632	0.378–1.021
	21.17±1.76	17.703±24.638		1
			0.810
Head	19.47±1.55	16.424–22.530
Non-head	18.52±1.79	15.009–22.041
			0.173
Well-moderate	20.34±1.40	17.628±23.120
Poor	15.68±2.77	10.241±21.133
			0.070
Absent	21.52±2.03	17.541–25.515
Present	17.03±1.28	14.521–19.540
						0.060
Absent	20.53±1.42	14.733–23.333		1.123	0.674–1.538
Present	14.89±1.69	11.579–18.203		1
			0.060
Absent	20.77±1.64	17.497–24.059
Present	16.17±1.47	13.294–19.059
						0.159
I–IIA	21.18±1.82	17.602–24.763		2.013	1.247–3.263
>IIB	16.21±1.31	13.638–18.792		1

T1–T2	23.81±2.34	19.218–28.404		2.334	1.359–4.010
>T3	16.18±1.11	13.977–18.378		1
			0.063
N0	20.70±1.68	17.407–23.995
N1	16.17±1.43	13.369–18.977
			0.144
High	18.00±2.01	14.076–21.924
Low	23.26±2.79	17.791–28.745

High	15.54±1.43	12.735–18.356		0.593	0.369–0.954
Low	20.83±1.57	17.753–23.907		1
P value in bold is statistically significant. T – tumor; N – lymph node.