The Prognostic Role of Glutathione Peroxidase 1 and Immune Infiltrates in Glioma Investigated Using Public Datasets

Shigang Lv; Haitao Luo; Kai Huang; Xingen Zhu

doi:10.12659/MSM.926440

21 October 2020: Database Analysis

The Prognostic Role of Glutathione Peroxidase 1 and Immune Infiltrates in Glioma Investigated Using Public Datasets

Shigang Lv ^12ABCDE* , Haitao Luo ^13ABCD* , Kai Huang ^12DEFG* , Xingen Zhu ^12ABCEFG*

DOI: 10.12659/MSM.926440

Med Sci Monit 2020; 26:e926440

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Table 1 Correlation analysis between GPX1 and gene markers of immune cells in TIMER.

Description	Gene markers	GBM				LGG
		None		Purity		None		Purity
		Cor	P	Cor	P	Cor	P	Cor	P
CD8+ T cell	CD8A	0.225	^*	0.151	0.079	0.126	^*	0.03	0.514
CD8+ T cell	CD8B	0.388	^***	0.307	^**	0.158	^**	0.068	0.137
T cell (general)	CD3D	0.563	^***	0.461	^***	0.453	^***	0.406	^***
	CD3E	0.408	^***	0.287	^**	0.459	^***	0.436	^***
	CD2	0.501	^***	0.38	^***	0.434	^***	0.41	^***
B cell	CD19	0.187	^*	0.17	0.047	0.416	^***	0.376	^***
B cell	CD79A	0.164	^*	0.16	0.062	0.374	^***	0.397	^***
Monocyte	CD86	0.475	^***	0.392	^***	0.779	^***	0.754	^***
	CCR2	0.377	^***	0.313	^**	0.413	^***	0.394	^***
	CD14	0.528	^***	0.357	^***	0.722	^***	0.708	^***
TAM	CCL2	0.372	^***	0.183	0.032	0.46	^***	0.423	^***
	CD68	0.514	^***	0.339	^***	0.809	^***	0.794	^***
	IL10	0.616	^***	0.438	^***	0.515	^***	0.469	^***
M1 Macrophage	CCL5	0.473	^***	0.355	^***	0.476	^***	0.453	^***
	IRF5	0.387	^***	0.175	0.040	0.769	^***	0.745	^***
	IL18	0.706	^***	0.573	^***	0.823	^***	0.806	^***
M2 Macrophage	CD163	0.374	^***	0.204	0.017	0.526	^***	0.527	^***
	VSIG4	0.671	^***	0.544	^***	0.717	^***	0.694	^***
	MS4A4A	0.614	^***	0.472	^***	0.673	^***	0.67	^***
Neutrophils	CD66b (CEACM8)	−0.23	^*	−0.296	^**	−0.004	0.92	−0.012	0.791
	CD11b (ITGAM)	0.304	^**	0.063	0.464	0.687		0.645	^***
	CCR7	0.305	^**	0.214	0.011	0.274		0.26	^***
Natural killer cell	NCR3	0.308	^*	0.238	0.005	0.198		0.184	^**
	CD127	0.291	^*	0.132	0.124	0.234		0.192	^***
	KIR2DL1	0.089	0.273	0.043	0.618	−0.021	0.633	0.004	0.923
Dendritic cell	HLA-DPB1	0.521	^***	0.386	^***	0.677	^***	0.653	^***
	HLA-DRA	0.64	^***	0.527	^***	0.666	^***	0.642	^***
	HLA-DPA1	0.478	^***	0.362	^***	0.617	^***	0.591	^***
	BDCA-1(CD1C)	0.361	^***	0.191	0.025	0.339	^***	0.328	^***
Th1	CD4	0.436	^***	0.242	^*	0.754	^***	0.727	^***
	CD103	0.34	^***	0.413	^***	0.147	^**	0.168	^**
	TNF-α(TNF)	0.266	^**	0.118	0.169	0.231	^***	0.181	^***
Th2	CD14	0.528	^***	0.357	^***	0.722	^***	0.708	^***
Th2	IL13	−0.243	0.025	−0.209	0.014	0.045	0.303	0.048	0.291
Tfh	BCL6	−0.355	^***	−0.405	^***	0.145	^**	0.176	^**
Tfh	IL21	−0.014	0.868	0.021	0.807	0.095	0.031	0.073	0.113
Th17	STAT3	−0.361	^***	−0.371	^***	0.328	^***	0.332	^***
Th17	IL17A	−0.058	0.476	−0.146	0.089	−0.025	0.578	−0.042	0.365
Treg	CD103	0.34	^***	0.413	^***	0.147	^**	0.168	^**
	CCR8	0.254	^*	0.177	0.039	0.162	^**	0.166	^**
	STAT5B	−0.606	^***	−0.525	^***	−0.185	^***	−0.127	^*
T cell exhaustion	PD-1(PDCD1)	0.284	^**	0.216	0.011	0.538	^***	0.522	^***
	TIM-3 (HAVCR2)	0.62	^***	0.479	^***	0.805	^***	0.788	^***
	GZMB	0.369	^***	0.237	^*	0.182	^***	0.202	^***
TIMER – Tumor Immune Estimation Resource; TAM – tumor-associated macrophage; Th – T helper cell; Tfh – follicular helper T cell; Treg – regulatory T cell; Cor – R value of Spearman’s correlation; None – correlation without adjustment; Purity – correlation adjusted by purity. ^* ^ ^*

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The Prognostic Role of Glutathione Peroxidase 1 and Immune Infiltrates in Glioma Investigated Using Public Datasets

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