26 September 2020 : Database Analysis
Prognostic Value of Acute-On-Chronic Liver Failure (ACLF) Score in Critically Ill Patients with Cirrhosis and ACLF
Xinran Lin1ABCDEF, Xielin Huang2ABCDEF, Li Wang1BC, Shuyi Feng1B, Xiaofu Chen1BC, Weimin Cai1B, Zhiming Huang1A*DOI: 10.12659/MSM.926574
Med Sci Monit 2020; 26:e926574
Table 2 Laboratory parameters and clinical model scores of cirrhotic patients in this study, stratified by mortality (n=786, day=28).
| Variables | All patients (n=786) [n (%)] | Survivors (n=559) [n (%)] | Nonsurvivors (n=227) [n (%)] | P value* |
|---|---|---|---|---|
| Laboratory parameters | ||||
| ALT (IU/l) | 39.5 (23.0–81.3) | 37.0 (22.0–76.3) | 52.0 (28.3–95.3) | 0.001 |
| AST (IU/l) | 79.0 (44.0–178.5) | 73.0 (42.0–147.0) | 109.5 (55.0–209.5) | <0.001 |
| Albumin (g/dl) | 2.8 (2.4–3.2) | 2.8 (2.4–3.3) | 2.6 (2.2–3.1) | <0.001 |
| Bilirubin (mg/dl) | 3.3 (1.4–8.0) | 2.7 (1.3–5.4) | 7.0 (2.7–17.5) | <0.001 |
| BUN (mg/dl) | 31 (19–51) | 27 (17–44) | 42 (27–64) | <0.001 |
| Creatinine (mg/dl) | 1.4 (0.9–2.6) | 1.2 (0.8–2.1) | 2.0 (1.3–3.4) | <0.001 |
| Glucose (mg/dl) | 101 (83–125) | 103 (87–128) | 94 (75–118) | <0.001 |
| Hematocrit | 26.9 (23.7–30.7) | 27.0 (24.0–30.7) | 26.2 (23.0–30.7) | 0.213 |
| Hemoglobin (mg/dl) | 9.1 (8.0–10.5) | 9.2 (8.1–10.6) | 9.1 (7.6–10.4) | 0.156 |
| Platelet (10/l) | 85 (55–137) | 92 (59–148) | 72 (51–113) | <0.001 |
| WBC (10/l) | 11.9 (8–17.9) | 11.2 (7.7–16.6) | 13.8 (8.4–20.9) | <0.001 |
| RDW | 17.2 (15.5–18.9) | 16.7 (15.2–18.4) | 18.0 (16.4–20.0) | <0.001 |
| INR | 1.8 (1.5–2.4) | 1.7 (1.4–2.1) | 2.4 (1.8–3.1) | <0.001 |
| PT | 18.7 (16–23.4) | 17.5 (15.4–21.1) | 22.4 (18.6–29.4) | <0.001 |
| Lactate (mg/dl) | 2.8 (1.9–4.8) | 2.5 (1.8–4.2) | 3.7 (2.3–7.4) | <0.001 |
| Potassium (mEq/l) | 4.6 (4.0–5.2) | 4.5 (4.0–5.1) | 4.7 (4.1–5.5) | 0.046 |
| Sodium (mEq/l) | 136 (131–139) | 136 (132–139) | 135 (129–139) | 0.017 |
| Clinical model scores | ||||
| Child-Pugh score | 9 (7–10) | 8 (7–10) | 10 (9–11) | <0.001 |
| MELD | 16 (9–24) | 15 (9–23) | 17 (10–26) | <0.001 |
| MELD-Na | 18 (11–29) | 17 (11–28) | 21 (11–30) | <0.001 |
| SOFA | 8 (5–11) | 7 (5–10) | 11 (9–14) | <0.001 |
| CLIF-SOFA | 9 (7–11) | 8 (6–10) | 11 (9–13) | <0.001 |
| AARC ACLF | 9 (8–10) | 9 (7–10) | 10 (9–12) | <0.001 |
| CLIF-C ACLFs | 52 (43–61) | 48 (40–57) | 62 (53–72) | <0.001 |
| * Student’s t-test or Mann-Whitney U-test was used for continuous variables, and χ-test or Fisher’s exact test was used for categorical variables. ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; WBC – white blood cell; RDW – red blood cell volume distribution width; INR – international normalized ratio; PT – prothrombin time; MELD – model for end-stage liver disease; SOFA – Sequential Organ Failure Assessment; CLIF-SOFA – Chronic Liver Failure-Sequential Organ Failure Assessment Score. | ||||