26 September 2020 : Database Analysis
Prognostic Value of Acute-On-Chronic Liver Failure (ACLF) Score in Critically Ill Patients with Cirrhosis and ACLF
Xinran Lin1ABCDEF, Xielin Huang2ABCDEF, Li Wang1BC, Shuyi Feng1B, Xiaofu Chen1BC, Weimin Cai1B, Zhiming Huang1A*DOI: 10.12659/MSM.926574
Med Sci Monit 2020; 26:e926574
Table 3 Univariate and multivariate Cox proportional hazards model of association between clinical parameters and 28-day mortality.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (years) | 0.995 | 0.984, 1.005 | 0.332 | |||
| Sex | 0.981 | 0.744, 1.294 | 0.893 | |||
| Ethnicity | ||||||
| White | Reference | Reference | Reference | |||
| Black | 0.528 | 0.279, 1.002 | 0.051 | |||
| Other | 1.706 | 1.259, 2.312 | 0.001 | |||
| MAP (mmHg) | 0.959 | 0.945, 0.972 | <0.001 | 0.977 | 0.958, 0.997 | 0.025 |
| PaO2/FiO2 | 0.999 | 0.998, 1.000 | 0.005 | 0.998 | 0.997, 0.999 | 0.004 |
| 24-h urine output (ml) | 0.999 | 0.999, 1.000 | <0.001 | |||
| Vasopressin used | 2.120 | 1.629, 2.761 | <0.001 | 1.582 | 1.097, 2.281 | 0.014 |
| Ventilator | 1.491 | 1.135, 1.957 | 0.004 | |||
| RRT | 1.908 | 1.317, 2.763 | 0.001 | |||
| ALT (IU/l) | 1.000 | 1.000, 1.001 | 0.009 | |||
| AST (IU/l) | 1.000 | 1.000, 1.000 | <0.001 | 1.000 | 1.000, 1.000 | 0.006 |
| Albumin (g/dl) | 0.823 | 0.644, 1.050 | 0.118 | 0.761 | 0.595, 0.975 | 0.031 |
| BUN (mg/dl) | 1.009 | 1.006, 1.013 | <0.001 | |||
| Glucose (mg/dl) | 0.993 | 0.990, 0.997 | 0.001 | |||
| Platelet (10/l) | 0.996 | 0.994, 0.998 | <0.001 | 0.997 | 0.995, 1.000 | 0.037 |
| WBC (10/l) | 1.025 | 1.012, 1.039 | <0.001 | 1.020 | 1.003, 1.038 | 0.019 |
| RDW | 1.111 | 1.062, 1.162 | <0.001 | |||
| Potassium (mEq/l) | 1.034 | 0.906, 1.180 | 0.619 | |||
| Sodium (mEq/l) | 0.977 | 0.959, 0.996 | 0.016 | |||
| AARC ACLF | 1.434 | 1.335, 1.539 | <0.001 | 1.375 | 1.247, 1.516 | <0.001 |
| Ascites | 1.357 | 1.027, 1.791 | 0.035 | |||
| Variceal bleeding | 1.138 | 0.790, 1.640 | 0.487 | |||
| SBP | 1.894 | 1.282, 2.799 | 0.003 | 1.850 | 1.129, 3.034 | 0.015 |
| HRS | 1.813 | 1.347, 2.440 | <0.001 | |||
| HRs and P values were estimated using Cox proportional hazard model. CI – confidence interval; HR – hazard ratio; MAP – mean arterial pressure; RRT – renal replacement therapy; ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; WBC – white blood cell; RDW – red blood cell volume distribution width; SBP – spontaneous bacterial peritonitis; HRS – hepatorenal syndrome. | ||||||