Prognostic Value of Acute-On-Chronic Liver Failure (ACLF) Score in Critically Ill Patients with Cirrhosis and ACLF

26 September 2020 : Database Analysis

Xinran Lin^1ABCDEF, Xielin Huang^2ABCDEF, Li Wang^1BC, Shuyi Feng^1B, Xiaofu Chen^1BC, Weimin Cai^1B, Zhiming Huang^1A*

DOI: 10.12659/MSM.926574

Med Sci Monit 2020; 26:e926574

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Table 4 Diagnostic accuracy of scoring systems at cutoff points and at different time periods.

Prognostic models	28-day AUROC	P value*	90-day AUROC	P value*	180-day AUROC	P value*
AARC ACLF	0.754	–	0.747	–	0.728	–
Child-Pugh score	0.688	<0.001	0.692	<0.001	0.673	<0.001
MELD	0.753	0.970	0.749	0.904	0.727	0.909
MELD-Na	0.747	0.637	0.738	0.517	0.723	0.715
SOFA	0.766	0.486	0.753	0.723	0.739	0.504
CLIF-SOFA	0.743	0.459	0.745	0.878	0.727	0.888
CLIF-C ACLFs	0.777	0.144	0.762	0.310	0.745	0.272
AUROC – area under the receiver operating characteristic curve; MELD – model for end-stage liver disease; SOFA – Sequential Organ Failure Assessment; CLIF-SOFA – Chronic Liver Failure-Sequential Organ Failure Assessment Score. ^* DeLong test was used to compare the performance of each scoring systems with AARC ACLF.

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