13 October 2020 : Animal Research
Interaction of Orexin A and Vasopressin in the Brain Plays a Role in Blood Pressure Regulation in WKY and SHR Rats
Stanisław Kowalewski1ABDEF, Katarzyna Czarzasta1ADEF*, Liana Puchalska1CDE, Ewa Szczepańska-Sadowska1ADE, Agnieszka Wsol1BDE, Agnieszka Cudnoch-Jędrzejewska1EFGDOI: 10.12659/MSM.926825
Med Sci Monit 2020; 26:e926825
Table 1 Characteristic of the experimental groups.
| Group of rats | Number of rats | Body weight (g) | Resting MABP (mmHg) |
|---|---|---|---|
| WKY-NaCl | n=5 | 286±13.67 | 110±2.16 |
| SHR-NaCl | n=5 | 280±2.94 | 154±5.70* |
| WKY-DMSO | n=5 | 279±14.58 | 110±2.63 |
| SHR-DMSO | n=5 | 286±5.50 | 159±7.05* |
| WKY-V1aRANT | n=5 | 285±6.05 | 117±5.10 |
| SHR-V1aRANT | n=6 | 281±7.84 | 170±5.63* |
| WKY-OXA | n=5 | 284±9.91 | 113±2.74 |
| SHR-OXA | n=5 | 283±8.99 | 157±3.80* |
| WKY-OXA+V1aRANT | n=5 | 284±10.33 | 117±2.48 |
| SHR-OXA+V1aRANT | n=8 | 283±5.35 | 168±6.04* |
| WKY-NaCl – WKY rats receiving intracerebroventricular (ICV) infusion of vehicle; SHR-NaCl – SHR rats receiving ICV infusion of vehicle; WKY-DMSO – WKY rats receiving ICV infusion of dimethyl sulfoxide; SHR-DMSO – SHR rats receiving ICV infusion of dimethyl sulfoxide; WKY-V1aRANT – WKY rats receiving ICV infusion of a non-peptide V1aR antagonist; SHR-V1aRANT – SHR rats receiving ICV infusion of a non-peptide V1aR antagonist; WKY-OXA – WKY rats receiving ICV infusion of orexin A; SHR-OXA – SHR rats receiving ICV infusion of orexin A; WKY-OXA+V1aRANT – WKY rats receiving ICV infusion of orexin A combined with ICV infusion of a non-peptide V1aR antagonist; SHR-OXA+V1aRANT – WKY rats receiving ICV infusion of orexin A combined with ICV infusion of a non-peptide V1aR antagonist; MABP – mean arterial blood pressure. Means±SE are shown. * p | |||