11 December 2020 : Review article
Preoperative Intranasal Decolonization with Topical Povidone-Iodine Antiseptic and the Incidence of Surgical Site Infection: A Review
Vidmi Taolam Martin1ABCDEF, Mohamed Abdullahi Abdi1ABEF, Jie Li1BCEF, Dongtai Li1BCDF, Zhaozhen Wang1BCDE, Xianliao Zhang1BDEF, Welera Haissou Elodie2BCEF, Bo Yu1ABCDEF*DOI: 10.12659/MSM.927052
Med Sci Monit 2020; 26:e927052
Table 2 Summary of microorganism species and treatment in patients undergoing surgery from included studies.
| Fisrt author | Type(s) of surgery | Microorganisms species () | Treatment | Main result |
|---|---|---|---|---|
| Bebko SP [], 201521 | Elective orthopedic surgery with hardware implants | Coinfection of and Enterococcus (2 cases)S. aureus (1 case) | NA | Preoperative Methicillin-resistant decontamination with CHG, mouth wash regimen, and intranasal povidone-iodine reduced about 50% the rate of surgical site infection in patients planned for surgery |
| Phillips M [], 201622 | Arthroplasty or spine fusion surgery | MRSA (1 case)Coagulase-negative staphylococci (1 case) (1 case) (1 case) (1 case) (1 case) | Cefazolin (1 g)Clindamycin (600 mg)Vancomycin (1 g) | deep SSI occurred in 5 of 763 in the mupirocin group and 0 of 776 in the povidone-iodine group (P=0.03). Intranasal povidone-iodine may be admitted as an elective strategy to reduce surgical site infection |
| Rezapoor M [], 201723 | Primary or revision TJA, FAO, PO, or TSA | (7 cases), at 4 hours post-treatment (20 cases), at 24 hours post-treatment | CefazolinVancomycin | PI-SNA regimen was significantly more effective at decolonizing at 4 hours post-treatment (P=0.003), comparing to the other three groups. There is no significant difference at 24 hours post-treatment between the three groups |
| Urias DS [], 201824 | Repair of lower extremity fractures | (2 cases) | NA | A 0.2% infection rate was noted among subjects in the intervention group (962) with P=0.020, however, in the pre-intervention group (930), a 1.1% infection rate was observed. PI-SNA regimen showed a significant decrease in the infection rate of subjects planned for surgery |
| Peng HM [], 201825 | Elective orthopedic surgery | MRSA (8) (64) | Cefuroxime (1.5 mg)Clindamycin (600 mg)Vancomycin (1 g) | The decolonization of the MSSA was 94%, while the decolonization of the MRSA was 100% successful |
| MRSA – methicillin-resistant ; NA – not available; CHG – chlorhexidine; PI-SNA – povidone-iodine skin and nasal antiseptic; – ; – ; – – – . | ||||