Integrated Bioinformatics Analysis of Hub Genes and Pathways Associated with a Compression Model of Spinal Cord Injury in Rats

05 November 2020 : Laboratory Research

Chang Jiang^1BCE, Zheng Li^1BCE, Zhaoyi Wu^1DEF, Yun Liang^1CD, Lixia Jin^1BD, Yuanwu Cao^1CG, Shengcheng Wan^1DG, Zixian Chen^1AG*

DOI: 10.12659/MSM.927107

Med Sci Monit 2020; 26:e927107

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Table 1 Top 3 up or down genes by comparing average FPKM between different days post-injury and Sham group.

	Up			Down
	Gene	Log2(FC)	FDR	Gene	Log2(FC)	FDR
1 d Sham		4.26	0.02		−3.86	0.00
		3.81	0.04		−4.5	0.00
		3.49	0.00		−5.04	0.07
3 d Sham		1.16	0.04		−0.98	0.01
		0.99	0.04		−1.09	0.03
		0.74	0.03		−1.16	0.03
5 d Sham		2.54	0.03		−1.36	0.02
		2.12	0.03		−1.6	0.04
		2.04	0.04		−2.22	0.03
7 d Sham		3.66	0.01		−5.63	0.02
		3.25	0.02		−6.42	0.01
		2.95	0.03		−6.74	0.01
Log2(FC) – log2 fold change; FDR – adjusted values obtained applying the Benjamini-Hochberg method.

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