Comparison of Incidence and Outcomes of Neuroblastoma in Children, Adolescents, and Adults in the United States: A Surveillance, Epidemiology, and End Results (SEER) Program Population Study

Ping Yan; Feng Qi; Lanzheng Bian; Yajuan Xu; Jing Zhou; Jiajie Hu; Lei Ren; Mei Li; Weibin Tang

doi:10.12659/MSM.927218

29 November 2020 : Database Analysis

Comparison of Incidence and Outcomes of Neuroblastoma in Children, Adolescents, and Adults in the United States: A Surveillance, Epidemiology, and End Results (SEER) Program Population Study

Ping Yan^1AB, Feng Qi^2BE, Lanzheng Bian^3BC, Yajuan Xu^1BD, Jing Zhou^3D, Jiajie Hu^3F, Lei Ren^3CE, Mei Li^3AG*, Weibin Tang^1AFG

DOI: 10.12659/MSM.927218

Med Sci Monit 2020; 26:e927218

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Table 2 Multivariate Cox proportional hazards regression analyses evaluating factors influencing overall survival in patients with neuroblastoma.

Variables	All patients			Childhood patients			Adolescent/adult patients
Variables	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Age category
Children	Reference
Adolescents/adults	3.417	2.811–4.154	<0.001
Sex			0.301			0.204			0.660
Male	Reference			Reference			Reference
Female	0.941	0.838–1.056	0.301	0.924	0.817–1.044	0.204	0.919	0.631–1.339	0.660
Race			0.117			0.143			0.758
White	Reference			Reference			Reference
Black	1.181	1.003–1.391	0.046	1.185	0.995–1.412	0.057	1.124	0.682–1.851	0.646
Other	1.094	0.877–1.364	0.427	1.090	0.867–1.371	0.461	1.341	0.551–3.264	0.517
Sequence
First primary	Reference			Reference			Reference
Not first primary	4.092	2.472–6.772	<0.001	3.824	1.574–9.291	0.003	4.725	2.323–9.656	<0.001
SEER stage									0.052
Localized	Reference			Reference			Reference
Regional	1.756	1.316–2.344	<0.001	2.504	1.703–3.680	<0.001	1.422	0.834–2.425	0.196
Distant	5.803	4.497–7.490	<0.001	9.266	6.520–13.168	<0.001	1.879	1.130–3.124	0.015
Histology									0.540
Ganglioneuro-blastoma	Reference			Reference			Reference
Neuroblastoma	1.306	1.058–1.611	0.013	1.365	1.071–1.741	0.012	1.159	0.723–1.859	0.540
Primary site
Abdomen	Reference			Reference			Reference
Mediastinum/thorax	0.347	0.268–0.451	<0.001	0.347	0.264–0.458	<0.001	0.300	0.127–0.710	0.006
Nerve system	1.108	0.855–1.436	0.439	0.984	0.708–1.367	0.921	1.564	0.919–2.664	0.099
Head and neck	0.679	0.462–1.000	0.050	0.573	0.336–0.978	0.041	0.786	0.423–1.460	0.445
Pelvis/extremities/vertebral	0.545	0.372–0.799	0.002	0.542	0.339–0.868	0.011	0.439	0.212–0.910	0.027
Surgery
No/unknown	Reference			Reference			Reference
Yes	0.658	0.581–0.746	<0.001	0.662	0.581–0.755	<0.001	0.468	0.293–0.749	0.002
Treatment era
1975–1984	Reference			Reference			Reference
1985–1994	0.646	0.530–0.787	<0.001	0.629	0.510–0.776	<0.001	0.608	0.311–1.189	0.146
1995–2004	0.496	0.414–0.593	<0.001	0.472	0.390–0.572	<0.001	0.400	0.224–0.712	0.002
2005–2013	0.348	0.289–0.419	<0.001	0.338	0.278–0.412	<0.001	0.287	0.157–0.522	<0.001
Median household income			0.229			0.222			0.620
Low-level	Reference			Reference			Reference
High-level	0.926	0.817–1.049	0.229	0.921	0.808–1.051	0.222	1.117	0.721–1.731	0.620
Place of residence			0.033			0.061			0.145
Urban	Reference			Reference			Reference
Rural	1.188	1.014–1.392		1.173	0.993–1.386	0.061	1.496	0.870–2.570	0.145
HR – hazard ratio, CI – confidence interval.

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Comparison of Incidence and Outcomes of Neuroblastoma in Children, Adolescents, and Adults in the United States: A Surveillance, Epidemiology, and End Results (SEER) Program Population Study

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