26 November 2020>: Database Analysis
The Clinical Significance of Dickkopf Wnt Signaling Pathway Inhibitor Gene Family in Head and Neck Squamous Cell Carcinoma
Yuan Hu ABCEF , Muyuan Liu CD , Shaowei Xu BD , Shaokun Li EF , Mingfeng Yang G , Tian Su B , Zihong Yuan C , Hanwei Peng AD*DOI: 10.12659/MSM.927368
Med Sci Monit 2020; 26:e927368
Table 1 Expression of DKKs at the transcription level in HNC and normal tissues (Oncomine).
Types of HNC vs. NC | Fold change | P value | t Test | Reference | |
---|---|---|---|---|---|
DKK1 | Oral cavity squamous cell carcinoma | 3.734 | 2.31E-14 | 9.378 | Peng et al. []15 |
Oral cavity squamous cell carcinoma | 1.666 | 0.005 | 2.872 | Toruner et al. []16 | |
DKK2 | Head and neck squamous cell carcinoma | −2.451 | 1.34E-06 | −5.311 | Ginos et al. []17 |
Oral cavity squamous cell carcinoma | −1.883 | 1.73E-10 | −8.124 | Peng et al. []15 | |
Floor of the mouth carcinoma | −2.963 | 1.86E-04 | −4.111 | Pyeon et al. []18 | |
Tongue carcinoma | −2.577 | 4.88E-04 | −3.743 | Pyeon et al. []18 | |
DKK3 | Nasopharyngeal carcinoma | 2.196 | 1.96E-05 | 4.777 | Sengupta et al. []19 |
DKK4 | Head and neck squamous cell carcinoma | −8.783 | 1.66E-10 | −8.783 | Ginos et al. []17 |
Oral cavity squamous cell carcinoma | −2.217 | 2.33E-11 | −9.586 | Peng et al. []15 | |
HNC – head and neck cancer; DKK – Dickkopf Wnt signaling pathway inhibitor; NC – normal control. |