28 October 2020>: Lab/In Vitro Research
Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-κB) Promotes Migration and Invasion of Gastric Cancer Cells
Jing Gong 1ABCDEF* , Yongxi Song 2AB* , Ling Xu 3ACEF , Xiaofang Che 3DEF , Kezuo Hou 3BC , Tianshu Guo 3BC , Yu Cheng 3ABG , Yunpeng Liu 3ADE* , Xiujuan Qu 3AG*DOI: 10.12659/MSM.927411
Med Sci Monit 2020; 26:e927411
Table 1 Correlation between CXCR4/SERPINB3 levels and clinicopathological factors in patients with primary GC.
Factors | Cases | CXCR4 | SERPINB3 | ||||||
---|---|---|---|---|---|---|---|---|---|
Neg (%) | Pos (%) | χ2 | P value | Neg (%) | Pos (%) | χ2 | P value | ||
Sex | |||||||||
Male | 73 | 24 (25.0) | 49 (51.0) | 33 (34.4) | 40 (41.7) | ||||
Female | 23 | 6 (6.3) | 17 (17.7) | 0.375 | 0.54 | 12 (12.5) | 11 (11.5) | 0.341 | 0.559 |
Age | |||||||||
46 | 15 (15.6) | 31 (32.3) | 23 (24.0) | 23 (24.0) | |||||
≥60 | 50 | 15 (15.6) | 35 (36.5) | 0.076 | 0.783 | 22 (22.9) | 28 (29.2) | 0.346 | 0.556 |
T stage | |||||||||
T1+T2+T3 | 28 | 11 (11.5) | 17 (17.7) | 14 (14.6) | 14 (14.6) | ||||
T4 | 68 | 19 (19.8) | 49 (51.0) | 1.188 | 0.276 | 31 (32.3) | 37 (38.5) | 0.155 | 0.694 |
LN metastasis | |||||||||
N0 | 23 | 13 (13.5) | 10 (10.4) | 18 (18.8) | 5 (5.2) | ||||
N1–N3 | 73 | 17 (17.7) | 56 (58.3) | 8.991 | 0.003* | 27 (28.1) | 46 (47.9) | 11.965 | 0.001* |
Lauren classification | |||||||||
Intestinal | 43 | 12 (12.5) | 31 (32.3) | 19 (19.8) | 24 (25.0) | ||||
Others | 53 | 18 (18.8) | 35 (36.5) | 0.405 | 0.524 | 26 (27.1) | 27 (28.1) | 0.226 | 0.634 |
LN – lymph node. * |
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