28 October 2020>: Lab/In Vitro Research
Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-κB) Promotes Migration and Invasion of Gastric Cancer Cells
Jing Gong 1ABCDEF* , Yongxi Song 2AB* , Ling Xu 3ACEF , Xiaofang Che 3DEF , Kezuo Hou 3BC , Tianshu Guo 3BC , Yu Cheng 3ABG , Yunpeng Liu 3ADE* , Xiujuan Qu 3AG*DOI: 10.12659/MSM.927411
Med Sci Monit 2020; 26:e927411
Table 4 Correlation between SERPINB3 levels and clinicopathological factors in CXCR- positive patients with GC.
Factors | Cases | SERPINB3 | |||
---|---|---|---|---|---|
Neg (%) | Pos (%) | χ2 | P value | ||
Sex | |||||
Male | 49 | 20 (30.3) | 29 (43.9) | ||
Female | 17 | 6 (9.1) | 11 (16.7) | 0.161 | 0.688 |
Age | |||||
31 | 13 (19.7) | 18 (27.3) | |||
≥60 | 35 | 13 (19.7) | 22 (33.3) | 0.158 | 0.691 |
T stage | |||||
T1+T2+T3 | 17 | 6 (9.1) | 11 (16.7) | ||
T4 | 49 | 20 (30.3) | 29 (43.9) | 0.161 | 0.688 |
LN metastasis | |||||
N0 | 10 | 7 (10.6) | 3 (4.5) | ||
N1–3 | 56 | 19 (28.8) | 37 (56.1) | 4.624 | 0.041* |
Lauren classification | |||||
Intestinal | 31 | 10 (15.2) | 21 (31.8) | ||
Others | 35 | 16 (14.2) | 19 (28.8) | 1.247 | 0.264 |
GC – gastric cancer; LN – lymph node. * |
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