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28 October 2020: Lab/In Vitro Research

Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-κB) Promotes Migration and Invasion of Gastric Cancer Cells

Jing Gong 1ABCDEF* , Yongxi Song 2AB* , Ling Xu 3ACEF , Xiaofang Che 3DEF , Kezuo Hou 3BC , Tianshu Guo 3BC , Yu Cheng 3ABG , Yunpeng Liu 3ADE* , Xiujuan Qu 3AG*

DOI: 10.12659/MSM.927411

Med Sci Monit 2020; 26:e927411

Table 4 Correlation between SERPINB3 levels and clinicopathological factors in CXCR- positive patients with GC.

FactorsCasesSERPINB3
Neg (%)Pos (%)χ2P value
Sex
 Male4920 (30.3)29 (43.9)
 Female176 (9.1)11 (16.7)0.1610.688
Age
3113 (19.7)18 (27.3)
 ≥603513 (19.7)22 (33.3)0.1580.691
T stage
 T1+T2+T3176 (9.1)11 (16.7)
 T44920 (30.3)29 (43.9)0.1610.688
LN metastasis
 N0107 (10.6)3 (4.5)
 N1–35619 (28.8)37 (56.1)4.6240.041*
Lauren classification
 Intestinal3110 (15.2)21 (31.8)
 Others3516 (14.2)19 (28.8)1.2470.264
GC – gastric cancer; LN – lymph node.
*
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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750