28 October 2020: Lab/In Vitro Research
Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-κB) Promotes Migration and Invasion of Gastric Cancer Cells
Jing Gong 1ABCDEF* , Yongxi Song 2AB* , Ling Xu 3ACEF , Xiaofang Che 3DEF , Kezuo Hou 3BC , Tianshu Guo 3BC , Yu Cheng 3ABG , Yunpeng Liu 3ADE* , Xiujuan Qu 3AG*DOI: 10.12659/MSM.927411
Med Sci Monit 2020; 26:e927411
Table 5 Correlation between SERPINB3 levels and clinicopathological factors in CXCR4 negative patients with GC.
| Factors | Cases | SERPINB3 | |||
|---|---|---|---|---|---|
| Neg (%) | Pos (%) | χ2 | P value | ||
| Sex | |||||
| Male | 24 | 13 (43.3) | 11 (36.7) | ||
| Female | 6 | 6 (20) | 0 (0) | 4.342 | 0.061 |
| Age | |||||
| 15 | 10 (33.3) | 5 (16.7) | |||
| ≥60 | 15 | 9 (30) | 6 (20) | 0.144 | 0.705 |
| T stage | |||||
| T1+T2+T3 | 11 | 8 (26.7) | 3 (10) | ||
| T4 | 19 | 11 (36.7) | 8 (26.7) | 0.660 | 0.466 |
| LN metastasis | |||||
| N0 | 13 | 11 (36.7) | 2 (6.7) | ||
| N1–3 | 17 | 8 (26.7) | 9 (30.0) | 4.474 | 0.057 |
| Lauren classification | |||||
| Intestinal | 12 | 9 (30) | 3 (10) | ||
| Others | 18 | 10 (33.3) | 8 (26.7) | 1.172 | 0.442 |
| GC – gastric cancer; LN – lymph node. | |||||
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