02 January 2021 : Clinical Research
Association Between Thyroid Function and Body Composition in Type 2 Diabetes Mellitus (T2DM) Patients: Does Sex Have a Role?
Lu Chen12ABCDEFG*, Min Zhang2BCF, Shoukui Xiang1BCF, Xiaohong Jiang1BCD, Hongliu Gu2CF, Qi Sha2CD, Meidi Qu2D, Ting Xu3AEGDOI: 10.12659/MSM.927440
Med Sci Monit 2021; 27:e927440
Table 2 Comparison of general data and body composition parameters between male and female groups after propensity score matching.
| Group | Female groupN=159 | Male groupN=159 | P value |
|---|---|---|---|
| Age (years) | 57.63±12.12 | 56.98±12.99 | 0.6460 |
| Disease course (years) | 8.23±6.18 | 7.67±6.39 | 0.4250 |
| Systolic pressure (mmHg) | 136.52±16.71 | 135.31±16.22 | 0.5115 |
| Diastolic pressure (mmHg) | 82.65±8.69 | 82.72±10.76 | 0.9497 |
| Fasting blood glucose (mmol/L) | 8.53±2.44 | 8.36±2.32 | 0.5272 |
| Fasting C-peptide (pmol/L) | 1.94±1.11 | 1.92±1.31 | 0.8773 |
| Modified HOMA-IR | 3.43±1.09 | 3.41±1.41 | 0.9093 |
| Modified HOMA-islet | 45.29±38.05 | 45.02±36.32 | 0.9483 |
| HbA1c (%) | 9.59±2.39 | 9.71±2.80 | 0.6767 |
| Uric acid (μmol/L) | 281.71±89.81 | 296.92±79.32 | 0.1105 |
| Total cholesterol (mmol/L) | 4.53±0.99 | 4.40±1.25 | 0.3296 |
| Triacylglycerol (mmol/L) | 2.28±1.67 | 2.26±2.79 | 0.9621 |
| High-density lipoprotein (mmol/L) | 1.08±0.24 | 1.03±0.25 | 0.1173 |
| Low-density lipoprotein (mmol/L) | 2.43±0.71 | 2.35±0.83 | 0.3612 |
| BMI (kg/m) | 24.34±3.71 | 24.31±3.41 | 0.9423 |
| WC (cm) | 86.54±9.97 | 88.71±10.02 | 0.0531 |
| HC (cm) | 93.76±6.04 | 96.52±5.70 | <0.0001 |
| WHR | 0.92±0.06 | 0.92±0.06 | 0.6329 |
| EW (kg) | 11.65±1.39 | 14.86±1.68 | <0.0001 |
| BFM (kg) | 21.17±7.31 | 18.31±6.58 | 0.0003 |
| TBMM (kg) | 38.62±4.63 | 49.79±5.94 | <0.0001 |
| LBM (kg) | 41.00±4.89 | 52.72±6.31 | <0.0001 |
| SMM (kg) | 22.12±2.91 | 29.23±3.85 | <0.0001 |
| PBF | 33.30±5.83 | 25.22±6.14 | <0.0001 |
| FFMI (kg/m) | 16.06±1.43 | 18.02±1.71 | <0.0001 |
| PFFM | 0.67±0.06 | 0.75±0.06 | <0.0001 |
| SMI (kg/m) | 6.36±0.70 | 7.59±0.73 | <0.0001 |
| PSMM | 0.36±0.03 | 0.41±0.03 | <0.0001 |
| FMI (kg/m) | 8.28±2.68 | 6.28±2.26 | <0.0001 |
| X50HZ phase angle | 4.84±0.54 | 5.35±0.72 | <0.0001 |
| BMR (kcal/day) | 1255.52±105.57 | 1508.74±136.38 | <0.0001 |
| RULMM (kg) | 2.12±0.40 | 2.98±0.48 | <0.0001 |
| LULMM (kg) | 2.08±0.39 | 2.90±0.48 | <0.0001 |
| TMM (kg) | 18.75±2.40 | 23.94±2.83 | <0.0001 |
| RLLMM (kg) | 6.05±0.86 | 8.19±1.04 | <0.0001 |
| LLLMM (kg) | 6.02±0.86 | 8.14±1.02 | <0.0001 |
| EWF | 0.39±0.01 | 0.38±0.01 | 0.0001 |
| VFA (cm) | 105.58±40.53 | 84.55±31.91 | <0.0001 |
| BCM (kg) | 26.49±3.20 | 34.30±4.22 | <0.0001 |
| TBW (kg) | 30.14±3.61 | 38.81±4.59 | <0.0001 |
| TSH (μIU/ml) | 2.50±1.24 | 2.22±1.05 | 0.0342 |
| FT3 (pmol/l) | 4.10±0.53 | 4.37±0.67 | 0.0002 |
| FT4 (pmol/l) | 16.05 ± 2.19 | 16.94 ± 2.34 | 0.0008 |
| Results in the table: Mean±SD/N (%). HbA1c – hemoglobin A1c; HOMA-IR – homeostasis model assessment for insulin resistance; HOMA-islet – homeostasis model assessment for islet beta-cell function; BMI – body mass index; WC – waist circumference; HC – hip circumference; WHR – waist-to-hip ratio; EW – extracellular water; BFM – body fat mass; TBMM – total body muscle mass; LBM – lean body mass; SMM – skeletal muscle mass; PBF – percentage of body fat; FFMI – fat-free mass index; PFFM – percentage of fat-free mass; SMI – skeletal muscle index; PSMM – percentage of skeletal muscle mass; FMI – fat mass index; BMR – basal metabolic rate; RULMM – right upper-limb muscle mass; LULMM – left upper-limb muscle mass; TMM – trunk muscle mass; RLLMM – right lower-limb muscle mass; LLLMM – left lower-limb muscle mass; EWF – extracellular water fraction; VFA – visceral fat area; BCM – body cell mass; TBW – total body water; TSH – thyrotropin; FT4 – free thyroxine; FT3 – free triiodothyronine. | |||