A Chinese Retrospective Multicenter Study of First-Line Chemotherapy for Advanced Pancreatic Cancer

Hanzhi Cui; Jingzhi Guan; Guochao Deng; Jiajia Yuan; Changjie Lou; Wen Zhang; Aiping Zhou; Yanqiao Zhang; Jun Zhou; Guanghai Dai

doi:10.12659/MSM.927654

26 October 2020 : Clinical Research

A Chinese Retrospective Multicenter Study of First-Line Chemotherapy for Advanced Pancreatic Cancer

Hanzhi Cui^12BCDEF*, Jingzhi Guan^2D, Guochao Deng^2B, Jiajia Yuan^3B, Changjie Lou^4B, Wen Zhang^5B, Aiping Zhou^5BD, Yanqiao Zhang^4D, Jun Zhou^3D, Guanghai Dai^6ADG

DOI: 10.12659/MSM.927654

Med Sci Monit 2020; 26:e927654

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Table 1 Baseline characteristics of the 322 patients in the trial.

Characteristic	AS (n=232)		AG (n=79)		FOLFIRINOX (n=11)		Total (n=322)		P value

	No.	%	No.	%	No.	%	No.	%
									0.275
Male	140	60.3	52	65.8	9	81.8	201	62.4
Female	92	39.7	27	34.2	2	18.2	121	37.6

(range)	59 (36–79)		59 (37–74)		56 (43–67)		58.5 (36–79)

									0.062
0	160	69.0	42	53.2	6	54.5	208	64.6
1	71	30.6	35	44.3	5	45.5	111	34.5
2	1	0.4	2	2.5	0	0.0	3	0.9

	87	39.0	30	40.5	2	20.0	119	38.8
Head	37	16.6	10	13.5	1	10.0	48	15.6	0.309
Body	48	21.5	19	25.7	3	30.0	70	22.8	0.574
Tail	47	21.1	15	20.3	4	40.0	66	21.5	0.852
Body+tail	4	1.8	0	0.0	0	0.0	4	1.3	0.49

									0.58
Poor	82	58.6	28	54.9	2	28.6	112	56.6
Moderate	56	40.0	22	43.1	5	71.4	83	41.9
High	2	1.4	1	2.0	0	0.0	3	1.5

									0.393
1	145	63.9	43	58.1	4	40.0	192	61.7
2	43	18.9	18	24.3	4	40.0	65	20.9
≥3	39	17.2	13	17.6	2	20.0	54	17.4


Liver	160	69.0	53	67.1	5	45.5	218	67.7	0.263
Lung	21	9.1	7	8.9	2	18.2	30	9.3	0.588
Bone	13	5.6	6	7.6	0	0.0	19	5.9	0.567
Lymph node	119	51.3	35	44.3	5	45.5	159	49.4	0.543
Adrenal gland	10	4.3	2	2.5	1	9.1	13	4.0	0.54

									0.376
Yes	50	21.6	23	29.1	3	27.3	76	23.6
No	182	78.4	56	70.9	8	72.7	246	76.4

									0.143
Normal	87	40.0	39	52.7	4	36.4	130	42.9
Abnormal	131	60.0	35	47.3	7	63.6	173	57.1

									0.508
Normal	34	15.3	14	18.4	3	27.3	51	16.5
Abnormal	188	84.7	62	81.6	8	72.7	258	83.5

									0.312
Normal	44	23.2	14	27.5	4	44.4	62	24.8
Abnormal	146	76.8	37	72.5	5	55.6	188	75.2

(range)	6 (2–23)		4 (2–12)		6 (3–16)		5 (2–23)

									0.79
Yes	44	19.0	15	19.0	3	27.3	62	19.3
No	188	81.0	64	81.0	8	72.7	260	80.7

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A Chinese Retrospective Multicenter Study of First-Line Chemotherapy for Advanced Pancreatic Cancer

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