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21 December 2020 : Clinical Research  

Retrospective Study of Clinical Features of COVID-19 in Inpatients and Their Association with Disease Severity

Hao Wang1AE, Yang Xing2CDEF, Xiaohong Yao3BD, Yang Li1C, Jietao Huang1CD, Jun Tang1BF, Shasha Zhu1CD, Ying Zhang1EG, Jun Xiao1G*

DOI: 10.12659/MSM.927674

Med Sci Monit 2020; 26:e927674

Table 2 Laboratory indices of patients with COVID-19.

Normal rangeTotal (N=61)Common group (N=37)Severe group (N=24)P value
White blood count, ×10/L4–105.4 (4.05–6.9)5.3 (4.19–7.02)5.4 1(3.68–6.77)0.74
14 (23.0%)6 (16.2%)8 (33.3%)0.12
 ≥447 (77.0%)31 (83.8%)16 (66.7%)
Neutrophil count, ×10/L1.8–6.33.39 (2.52–4.62)3.28 (2.46–4.24)4.07 (2.75–5.54)0.218
1 (1.6%)01 (4.2%)0.168
 ≥1.860 (98.4%)37 (100.0%)23 (95.8%)
Lymphocyte count, ×10/L1.1–3.21.28 (0.84–1.6)1.41 (1.19–1.78)0.91 (0.48–1.24)
23 (37.7%)7 (18.9%)16 (66.7%)
 ≥1.138 (62.3%)30 (81.1%)8 (33.3%)
Monocyte count, ×10/L0.1–0.60.39 (0.28–0.52)0.39 (0.32–0.52)0.38 (0.2–0.52)0.337
Red blood cell distribution width, %11–1612.6 (12.2–14.15)12.4 (12.2–14.25)12. 7(12.33–13.1)0.848
Platelet count, ×10/L125–350206 (157.5–251.5)217 (183.5–252)163.5 (133.25–248.25)0.066
5 (8.2%)1 (2.7%)4 (16.7%)0.052
 ≥12556 (91.8%)36 (97.3%)20 (83.3%)
Mean platelet volume, fl9–1310.1 (9.05–10.95)10.1(9–10.8)10.4(9.65–11.18)0.243
Albumin, g/L40–5537.8 (34.4–40.68)38.39(35.85–41.09)35(33.55–40.17)0.046
40 (66.7%)23 (62.2%)17 (73.9%)0.348
 ≥4020 (33.3%)14 (37.8%)6 (26.1%)
Aspartate aminotransferase, U/L15–4027.43 (19.67–34.69)21.4(15.04–29.69)31.57(25.69–40.06)0.014
 >405 (16.7%)2 (12.5%)3 (21.4%)0.513
 ≤4025 (83.3%)14 (87.5%)11 (78.6%)
Urea, mmol/L3.1–83.86 (2.9–5.1)3.33 (2.64–4.06)4.93 (4–6.4)
 >85 (8.3%)05 (20.8%)0.002
 ≤855 (91.7%)36 (100.0%)19 (79.2%)
Creatinine, μmol/L57–9763.63 (50.8–77.8)59.55 (44.32–71.52)71.5 (56.6–83.68)0.01
 >974 (6.7%)1 (2.8%)3 (12.5%)0.141
 ≤9756 (93.3%)35 (97.2%)21 (87.5%)
D-dimer, ng/mL0–1.50.42 (0.15–0.84)0.44 (0.18–0.84)0.4 (0.11–1.05)0.527
Prothrombin time, s10.5–13.511.5 (10.6–12.3)11.1 (10.6–11.8)12.1 (11.05–15.7)0.003
 >13.519 (32.2%)7 (20.0%)12 (50.0%)0.015
 ≤13.540 (67.8%)28 (80.0%)12 (50.0%)
Creatine kinase isoenzymes, U/L0–249.9 (7–13.25)9.25 (6.53–11.89)11.82 (7–19)0.079
Lactate dehydrogenase, U/L120–250195 (166.75–303.15)176.02 (162.5–204.93)253.94 (196.5–352.12)0.001
 >25016(29.6%)5 (15.6%)11 (50.0%)0.007
 ≤25038 (70.4%)27 (84.4%)11 (50.0%)
C-reactive protein, mg/L0–515.56 (0.9–49.22)2.08 (0.54–22.66)40.9 (9.7–70.58)
 >534 (57.6%)15 (41.7%)19 (82.6%)0.002
 ≤525 (42.4%)21 (58.3%)4 (17.4%)
Procalcitonin, μg/L0–0.50.08 (0.05–0.23)0.07 (0.05–0.18)0.1 (0.05–0.27)0.557
 >0.56 (11.3%)2 (6.3%)4 (19.0%)0.155
 ≤0.547 (88.7%)30 (93.7%)17 (81.0%)
Neutrophil-to-lymphocyte ratio, NLRNA (not available)2.88 (1.94–5.05)2.34 (1.55–3.86)4.72 (2.89–6.81)
Lymphocyte-to-monocyte ratio, LMRNA3.2 (2.25–4.24)3.6 (2.89–4.45)2.71 (1.84–3.19)0.004
Platelet-to-lymphocyte ratio, PLRNA170.07 (130.18–225.03)152.78 (122.06–185.18)213.49 (151.08–356.13)0.004
Mean platelet volume to lymphocyte ratio, MPVLRNA7.65 (5.97–13.3)7.03 (5.7–7.98)12.61 (7.33–21)
C-reactive protein to albumin ratio, CARNA0.43 (0.02–1.28)0.06 (0.01–0.6)1.09 (0.07–2.03)0.001

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750