Retrospective Study of Clinical Features of COVID-19 in Inpatients and Their Association with Disease Severity

Hao Wang; Yang Xing; Xiaohong Yao; Yang Li; Jietao Huang; Jun Tang; Shasha Zhu; Ying Zhang; Jun Xiao

doi:10.12659/MSM.927674

21 December 2020 : Clinical Research

Retrospective Study of Clinical Features of COVID-19 in Inpatients and Their Association with Disease Severity

Hao Wang^1AE, Yang Xing^2CDEF, Xiaohong Yao^3BD, Yang Li^1C, Jietao Huang^1CD, Jun Tang^1BF, Shasha Zhu^1CD, Ying Zhang^1EG, Jun Xiao^1G*

DOI: 10.12659/MSM.927674

Med Sci Monit 2020; 26:e927674

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Table 3 Results of logistic analysis of risk factors for disease severity.

Variables	Univariate analysis			Multivariate analysis
Variables	OR	95% CI	P	OR	95% CI	P
Sex (Male Female)	0.457	0.160–1.308	0.145
Age (<60 years vs. ≥60 years)	1.25	0.426–3.664	0.684
Respiratory rate (>20 breaths/min ≤20 breaths/min)	0.135	0.016–1.148	0.067
WBC (<4×10/L ≥4×10/L)	0.387	0.114–1.309	0.127
Neutrophil count (<1.8×10/L ≥1.8×10/L)	<0.001	––––––	1
Lymphocytes (<1.1×10/L ≥1.1×10/L)	0.117	0.036–0.380	<0.001	0.094	0.009–1.032	0.053
Platelet count (<125×10/L ≥125×10/L)	0.139	0.015–1.329	0.087
Albumin (<40 g/L ≥40 g/L)	0.58	0.185–1.819	0.35
Aspartate aminotransferase (≤40 U/L >40 U/L)	0.524	0.074–3.703	0.517
Urea (≤8 mmol/L >8 mmol/L)	<0.001	––––––	0.999
Creatinine (≤97 μmol/L >97 μmol/L)	0.2	0.020–2.049	0.175
D-dimer (>1.5 ng/mL ≤1.5 ng/mL)	0.49	0.117–2.056	0.33
Prothrombin time (>13.5 s ≤13.5 s)	0.25	0.079–0.791	0.018	0.014	0.001–0.341	0.009
Creatine kinase isoenzymes (>24 U/L ≤24 U/L)	0.202	0.020–2.077	0.179
Lactate dehydrogenas (≥250 U/L <250 U/L)	0.185	0.052–0.658	0.009
C-reactive protein (>5 mg/L ≤5 mg/L)	0.15	0.042–0.533	0.003	0.028	0.002–0.526	0.017
Procalcitonin (>0.5 μg/L vs. ≤0.5 μg/L)	0.283	0.047–1.712	0.169
NLR (>4.4 ≤4.4)	0.094	0.027–0.328	<0.001
LMR (<7.0 ≥7.0)	1.565	0.093–26.279	0.756
PLR (>200.8 ≤200.8)	0.112	0.032–0.387	0.001
MPVLR (>8.9 ≤8.9)	0.08	0.023–0.276	<0.001	0.026	0.002–0.349	0.006
CAR (>0.66 ≤0.66)	0.138	0.043–0.438	0.001

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Retrospective Study of Clinical Features of COVID-19 in Inpatients and Their Association with Disease Severity

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