Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study

21 January 2021 : Database Analysis

Dandan Zhou^1ABCEF*, Baohua Zhu^2ABCDF, Jie Jiang^2DEF, Guangquan Zhou^3CEF, Suming Zhou^4ADEF

DOI: 10.12659/MSM.927716

Med Sci Monit 2021; 27:e927716

Background Material and Methods Results Discussion Conclusions References

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Supplementary Table 2 Multiple linear regression analysis of MV duration in the NE, NE+VAS, VAS, and dopamine groups.

Parameter	Univariate (n=1909)			Multivariate (n=1909, stepwise elimination)
Parameter	Unstandardized B	95% CI	P value	Unstandardized B	95% CI	P value
Sex (Male)	6.717	−12.781~26.214	0.499
Age	−2.458	−3.167~−1.748		−1.907	−2.590~−1.224
Weight (kg)	0.725	0.354~1.096
Race (White)	−16.6	−38.426~5.227	0.136
Group (NE reference)			0.000
Vasopressin	−23.847	−88~40.305	0.466
NE+VAS	120.66	96.66~144.65		94.415	70.010~118.821
Dopamine	−80.036	−102.9~−57.17		−37.898	−60.548~−15.247	0.001
SOFA	2.950	−0.03~5.93	0.052	−6.316	−9.362~−3.270
APS-III	0.707	0.255~1.159	0.002
GCS	−13.483	−15.81~−11.156		−13.090	−15.509~−10.671
Lactate (mmol/L)	2.815	−2.181~7.811	0.269
PaO/FiO	−0.061	−0.134~0.013	0.106
Bilirubin (mg/dL)	1.754	−0.959~4.467	0.205
Platelets (k/μL)	0.005	−0.074~0.083	0.909
sCr (μmol/L)	−7.817	−13.984~−1.650	0.013
BUN	−0.229	−0.610~0.152	0.238
Hemoglobin	−0.107	−5.339~5.125	0.968
Heart rate (bpm)	0.526	0.019~1.034	0.042
CHF	82.67	61.312~104.02
Preexisting HF	−30.491	−94.637~33.656	0.351
Temperature	16.482	9.733~23.231		10.928	4.498~17.358	0.001
APS-III – Acute Physiology Score III; BUN – blood urea nitrogen; CHF – congestive heart failure; GCS – Glasgow Coma Score; HF – heart failure; MV – mechanical ventilation; NE – norepinephrine; sCR – serum creatinine; SOFA – Sequential Organ Failure Assessment; VAS – vasopressin.

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