21 January 2021 : Database Analysis
Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study
Dandan Zhou1ABCEF*, Baohua Zhu2ABCDF, Jie Jiang2DEF, Guangquan Zhou3CEF, Suming Zhou4ADEFDOI: 10.12659/MSM.927716
Med Sci Monit 2021; 27:e927716
Table 2 Outcomes in the patients.
| Variable | Group | P value | ||
|---|---|---|---|---|
| NE (n=1055) | NE+VAS (n=371) | Dopamine (n=438) | ||
| Mortality rate (%) | ||||
| 7-d | 105 (10%) | 85 (22.9%) | 45 (10.3%) | <0.001 |
| 28-d | 284 (26.9%) | 189 (50.9%) | 107 (24.4%) | <0.001 |
| 90-d | 409 (38.8%) | 232 (62.5%) | 161 (36.8%) | <0.001 |
| ICU LOS (h) | 231.76±235.84 | 347.52±312.16 | 171.52±171.93 | <0.001* |
| Hos LOS (d) | 15.58±12.9 | 17.44±14.53 | 13.07±10.62 | <0.001* |
| Mechanical ventilation (%) | 758 (71.8%) | 336 (90.6%) | 259 (59.1%) | <0.001 |
| Vent durations (h) | 47.77 (0, 173.8) | 148.3 (44,307) | 12.38 (0, 87.17) | <0.001 |
| New RRT (%) | 21 (2%) | 50 (41.5%) | 4 (0.9%) | <0.001** |
| AKI (%) | 257 (24.4%) | 154 (35.6%) | 91 (20.8%) | <0.001 |
| Increased heart rate (bpm) | 37.99±26.52 | 45.84±29.39 | 32.02±23.11 | <0.001 |
| Emerging arrhythmias (%) | 392 (37.2%) | 164 (44.2%) | 216 (49.3%) | <0.001 |
| Emerging malignant arrhythmias (%) | 46 (4.4%) | 42 (11.3%) | 22 (5%) | <0.001 |
| Reduced hemoglobin (g/dL) | 1.69±1.50 | 2.08±1.73 | 1.66±1.52 | <0.001 |
| Platelet decline (k/μL) | 71.48±80.32 | 100.09±97.51 | 70.21±76.81 | <0.001 |
| Data are presented as n (%), mean±SD, or median and interquartile range. values are comparisons between the NE, VAS, NE+VAS, and dopamine groups. * Using the Welch’s test; ** Using Fisher’s exact test. AKI – acute kidney injury; Hos LOS –time from transfer to ICU to discharge; ICU LOS – Intensive Care Unit length of stay; NE – norepinephrine; RRT – renal replacement therapy; SD – standard deviation; VAS – vasopressin; Vent durations – mechanical ventilation time. | ||||