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21 January 2021: Database Analysis

Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study

Dandan Zhou 1ABCEF** , Baohua Zhu 2ABCDF* , Jie Jiang 2DEF , Guangquan Zhou 3CEF , Suming Zhou 4ADEF*

DOI: 10.12659/MSM.927716

Med Sci Monit 2021; 27:e927716

Table 3 Demographic characteristics of and clinical baseline data for patients in the NE, NE+VAS, and dopamine groups after propensity score matching.

VariableGroupP value
NE (N=231)NE& VAS (N=231)Dopamine (N=231)
Age (y, mean±SD)69.53±14.0770.97±13.5872.04±12.860.192
Sex (% Male)126 (54.5%)133 (57.6%)124 (53.7%)0.676
Weight (kg)83.40±27.4583.80±25.6083.07±28.110.792
Temperature (°C)36.11 (35.6, 37.56)36 (35.44,37.56)36.11 (35.61, 37.7)0.294
Heart rate (bpm)88.76±18.0687.82±19.3985.58±19.330.831
CHF180 (77.9%)165 (71.4%)160 (69.3%)0.093
Preexisting HF219 (94.8%)226 (97.8%)226 (97.8%)0.100
Dobutamine16 (6.9%)27 (11.7%)22 (10%)0.211
Lactate (mmol/L)2.23±1.392.35±1.422.42±1.920.474*
Bilirubin (mg/dL)1.71±4.441.33±2.041.06±1.970.083*
sCR (μmol/L)2.01±1.822.07±1.722.09±1.600.744
BUN (mmol/L)38.08±24.8739.87±25.7840.03±26.920.652
Platelets (k/μL)223.24±135.05226.20±128.63234.30±109.100.124
Hemoglobin (g/dL)10.20±1.7910.28±1.7910.44±2.030.159
SOFA8 (6, 10)8 (5,10)7 (5,10)0.232
APS-III58 (46, 71)58 (46, 73)54 (44, 68)0.153
SAPS II47 (39, 53)48 (39, 56)45 (35,55)0.154
GCS10 (7, 14)11 (8, 14)11 (8, 14)0.412
PaO/FiO207 (118.6, 313.3)206 (122.5, 315)199 (135, 298)0.800
Matching variables: Age, sex, weight, temperature, HR, CHF, preexisting HF, dobutamine, APS-III, SAPS II, SOFA, GCS, lactate, bilirubin, PaO/FiO, platelets, creatinine, BUN, hemoglobin. Matching tolerance: NE+VAS: NE=0.02, NE+VAS: Dopamine=0.1.
* Using Welch’s test.
APS-III – Acute Physiology Score III; BUN – blood urea nitrogen; CHF – congestive heart failure; GCS – Glasgow Coma Scale; HF – heart failure; NE – norepinephrine; SAPS II –Simplified Acute Physiology Score II; sCR – serum creatinine; SD – standard deviation; SOFA – Sequential Organ Failure Assessment; VAS – vasopressin.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750