21 January 2021>: Database Analysis
Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study
Dandan Zhou 1ABCEF** , Baohua Zhu 2ABCDF* , Jie Jiang 2DEF , Guangquan Zhou 3CEF , Suming Zhou 4ADEF*DOI: 10.12659/MSM.927716
Med Sci Monit 2021; 27:e927716
Table 3 Demographic characteristics of and clinical baseline data for patients in the NE, NE+VAS, and dopamine groups after propensity score matching.
Variable | Group | P value | ||
---|---|---|---|---|
NE (N=231) | NE& VAS (N=231) | Dopamine (N=231) | ||
Age (y, mean±SD) | 69.53±14.07 | 70.97±13.58 | 72.04±12.86 | 0.192 |
Sex (% Male) | 126 (54.5%) | 133 (57.6%) | 124 (53.7%) | 0.676 |
Weight (kg) | 83.40±27.45 | 83.80±25.60 | 83.07±28.11 | 0.792 |
Temperature (°C) | 36.11 (35.6, 37.56) | 36 (35.44,37.56) | 36.11 (35.61, 37.7) | 0.294 |
Heart rate (bpm) | 88.76±18.06 | 87.82±19.39 | 85.58±19.33 | 0.831 |
CHF | 180 (77.9%) | 165 (71.4%) | 160 (69.3%) | 0.093 |
Preexisting HF | 219 (94.8%) | 226 (97.8%) | 226 (97.8%) | 0.100 |
Dobutamine | 16 (6.9%) | 27 (11.7%) | 22 (10%) | 0.211 |
Lactate (mmol/L) | 2.23±1.39 | 2.35±1.42 | 2.42±1.92 | 0.474* |
Bilirubin (mg/dL) | 1.71±4.44 | 1.33±2.04 | 1.06±1.97 | 0.083* |
sCR (μmol/L) | 2.01±1.82 | 2.07±1.72 | 2.09±1.60 | 0.744 |
BUN (mmol/L) | 38.08±24.87 | 39.87±25.78 | 40.03±26.92 | 0.652 |
Platelets (k/μL) | 223.24±135.05 | 226.20±128.63 | 234.30±109.10 | 0.124 |
Hemoglobin (g/dL) | 10.20±1.79 | 10.28±1.79 | 10.44±2.03 | 0.159 |
SOFA | 8 (6, 10) | 8 (5,10) | 7 (5,10) | 0.232 |
APS-III | 58 (46, 71) | 58 (46, 73) | 54 (44, 68) | 0.153 |
SAPS II | 47 (39, 53) | 48 (39, 56) | 45 (35,55) | 0.154 |
GCS | 10 (7, 14) | 11 (8, 14) | 11 (8, 14) | 0.412 |
PaO/FiO | 207 (118.6, 313.3) | 206 (122.5, 315) | 199 (135, 298) | 0.800 |
Matching variables: Age, sex, weight, temperature, HR, CHF, preexisting HF, dobutamine, APS-III, SAPS II, SOFA, GCS, lactate, bilirubin, PaO/FiO, platelets, creatinine, BUN, hemoglobin. Matching tolerance: NE+VAS: NE=0.02, NE+VAS: Dopamine=0.1. * Using Welch’s test. APS-III – Acute Physiology Score III; BUN – blood urea nitrogen; CHF – congestive heart failure; GCS – Glasgow Coma Scale; HF – heart failure; NE – norepinephrine; SAPS II –Simplified Acute Physiology Score II; sCR – serum creatinine; SD – standard deviation; SOFA – Sequential Organ Failure Assessment; VAS – vasopressin. |