21 January 2021 : Database Analysis
Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study
Dandan Zhou1ABCEF*, Baohua Zhu2ABCDF, Jie Jiang2DEF, Guangquan Zhou3CEF, Suming Zhou4ADEFDOI: 10.12659/MSM.927716
Med Sci Monit 2021; 27:e927716
Table 4 Outcomes after PSM in patients in the NE, NE+VAS, and dopamine groups.
| Variable | Group | P value | ||
|---|---|---|---|---|
| NE (n=231) | NE+VAS (n=231) | Dopamine (n=231) | ||
| Mortality rate (%) | ||||
| 7-d | 26 (11.3%) | 40 (17.3%) | 21 (9.1%) | 0.022 |
| 28-d | 61 (26.4%) | 106 (45.9%)* | 55 (23.8%) | <0.001 |
| 90-d | 87 (37.7%) | 130 (56.3%)* | 88 (38.1%) | <0.001 |
| ICU LOS (h) | 255.14±274.2 | 345.62±295.39 | 189.32±189.63 | <0.001** |
| Hos LOS (d) | 16.9±15.88 | 17.54±12.71 | 14.16±10.74* | 0.005** |
| Mechanical ventilation (%) | 178 (77.1%) | 203 (87.9%) | 149 (64.5%) | <0.001 |
| Vent durations (h) | 56 (2.25, 206) | 140 (38.67, 285.5)* | 32.32 (0, 143.8) | <0.001 |
| New RRT (%) | 6 (2.6%) | 24 (10.4%)* | 1 (0.4%) | <0.001 |
| AKI (%) | 66 (28.6%) | 91 (39.4%)* | 51 (22.1%) | <0.001 |
| Increased heart rate (bpm) | 37.27±23.42 | 48.18±30.19* | 34.24±24.99 | <0.001 |
| Emerging arrhythmias (%) | 136 (58.9%) | 107 (46.3%) | 131 (56.7%) | 0.015 |
| Emerging malignant arrhythmias (%) | 15 (6.5%) | 31 (13.4%)* | 9 (3.9%) | <0.001 |
| Reduced hemoglobin (g/dL) | 1.70±1.40 | 2.14±1.74* | 1.67±1.54 | 0.003** |
| Platelet decline (k/μL) | 72.03±85.88 | 107.65±98.13* | 68.29±67.88 | <0.001 |
| * Significant difference between this group and the other 2 groups; ** Using Welch’s test. AKI – acute kidney injury; Hos LOS – hospital length of stay; NE – norepinephrine; PSM – propensity score matching; RRT – renal replacement therapy; VAS – vasopressin. | ||||