Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study

21 January 2021 : Database Analysis

Dandan Zhou^1ABCEF*, Baohua Zhu^2ABCDF, Jie Jiang^2DEF, Guangquan Zhou^3CEF, Suming Zhou^4ADEF

DOI: 10.12659/MSM.927716

Med Sci Monit 2021; 27:e927716

Background Material and Methods Results Discussion Conclusions References

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Table 6 Multiple linear regression analysis of differences in ICU LOS among the NE, NE+VAS, and dopamine groups.

Parameter	Univariate (n=1864)			Multivariate (n=1864, stepwise elimination)
Parameter	Unstandardized B	95% CI	P value	Unstandardized B	95% CI	P value
Sex (Male)	7.562	−14.947~30.070	0.510
Age	−2.879	−3.700~−2.058	<0.001	−2.286	−3.081~−1.491	<0.00
Weight (kg)	0.788	0.360–1.215	<0.001
Race (White)	−7.801	−33.044~17.441	0.544
Group (NE reference)
NE+VAS	133.43	105.94~160.92	<0.001	113.38	85.2~141.5	<0.001
Dopamine	−90.363	−116.55~−64.171	<0.001	−28.89	−56.214~−1.569	0.038
SOFA	−0.189	−3.635~3.256	0.914	−10.57	−14.124~−7.017	<0.001
APS-III	0.432	−0.089~0.954	0.104
GCS	−11.605	−14.326~−8.884	<0.001	−12.42	−15.232~−9.608	<0.001
Lactate (mmol/L)	2.454	−3.280~8.188	0.401
PaO/FiO	−0.061	−0.146~0.023	0.155
Bilirubin	3.010	−0.178~6.198	0.064
Platelets(k/μL)	−0.034	−0.125~0.057	0.462
sCr (μmol/L)	−6.515	−13.617~0.587	0.072
BUN	−0.117	−0.557~0.324	0.603
Hemoglobin	−1.831	−7.894~4.232	0.554
Heart rate (bpm)	0.393	−0.191~0.977	0.187
CHF	68.027	43.125~92.928	<0.001	61.615	36.778~86.452	<0.001
Preexisting HF	−47.310	−121.32~26.7	0.210
Temperature	16.562	8.780~24.344	<0.001	9.362	1.910~16.813	0.014
Dobutamine	14.139	−25.537~53.815	0.485
APS-III – Acute Physiology Score III; BUN – blood urea nitrogen; CHR – congestive heart failure; GCS – Glasgow Coma Scale; HF – heart failure; ICU LOS – Intensive Care Unit length of stay; NE – norepinephrine; SOFA – Sequential Organ Failure Assessment; VAS – vasopressin.

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