Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study

21 January 2021: Database Analysis

Dandan Zhou ^1ABCEF** , Baohua Zhu ^2ABCDF* , Jie Jiang ^2DEF , Guangquan Zhou ^3CEF , Suming Zhou ^4ADEF*

DOI: 10.12659/MSM.927716

Med Sci Monit 2021; 27:e927716

Table 7 Multiple linear regression analysis of differences in hospital length of stay among the NE, NE+VAS, and dopamine groups.

Parameter	Univariate (n=1864)			Multivariate (n=1864, stepwise elimination)
Parameter	Unstandardized B	95% CI	P value	Unstandardized B	95% CI	P value
Sex (Male)	0.952	−0.216~2.119	0.11
Age	−0.195	−0.237~−0.153		−0.189	−0.231~−0.147
Weight (kg)	0.047	0.025–0.069
Race (White)	−0.061	−1.371~1.249	0.927
Group (NE reference)
NE+VAS	2.598	1.142~4.054		113.38	85.2~141.5
Dopamine	−2.993	−4.362~−1.625		−1.461	−2.879~−0.043	0.043
SOFA	0.064	−0.114~0.243	0.479	−0.236	−0.423~−0.049	0.014
APS-III	0.011	−0.016~0.038	0.420
GCS	−0.380	−0.523~−0.238		−0.419	−0.569~−0.269
Lactate (mmol/L)	0.07	−2.228~0.367	0.646
PaO/FiO	0.001	−0.004~0.005	0.728
Bilirubin	0.076	−0.09~0.241	0.370
Platelets(k/μL)	−0.004	−0.008~0.001	0.133
sCr (μmol/L)	−0.023	−0.391~0.346	0.904
BUN	−0.013	−0.036~0.010	0.253
Hemoglobin	−0.082	−0.396~0.233	0.611
Heart rate (bpm)	−0.002	−0.032~0.029	0.910
CHF	2.415	1.118~3.712		2.015	0.689~3.340	0.003
Preexisting HF	−4.496	−8.322~−0.660	0.022	−3.764	−7.486~−0.041	0.048
Temperature	0.683	0.279~1.088	0.001
Dobutamine	−0.434	−2.493~1.625	0.679
APS-III – Acute Physiology Score III; BUN – blood urea nitrogen; CHF – congestive heart failure; HF – heart failure; NE – norepinephrine; NE – norepinephrine; sCR – serum creatinine; SOFA – Sequential Organ Failure Assessment; VAS –vasopressin.