01 February 2021: Clinical Research
Presence of Metabolic Syndrome and Thyroid Nodules in Subjects with Colorectal Polyps
Yue Yu ABCDEF , Jiansheng Wu ADE*DOI: 10.12659/MSM.927935
Med Sci Monit 2021; 27:e927935
Table 2 Baseline features and independent risk factors in colorectal adenoma.
| Basic information | Adenomas (1379) | Non-adenoma (3135) | P value | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | ||||
| Age (years) | 52 (45–59) | 46(40–53) | 0.000 | 1.053 (1.045–1.062) | 0.000 | 1.055 (1.045–1.065) | 0.000 |
| Sex (Male) | 507 (75.2) | 2293(59.7) | 0.000 | 2.048 (1.700–2.468) | 0.000 | 1.787 (1.333–2.395) | 0.000 |
| BMI (kg/m) | 24.4 (±3.1) | 23.5 (21.4–25.7) | 0.000 | 1.083 (1.056–1.112) | 0.000 | 1.028 (0.995–1.063) | 0.099 |
| TC (mmol/L) | 5.35 (4.67–6.07) | 5.21 (4.60–5.92) | 0.018 | 1.079 (1.002–1.163) | 0.044 | 0.938 (0.684–1.286) | 0.691 |
| TG (mmol/L) | 1.59 (1.09–2.40) | 1.38 (0.96–2.11) | 0.000 | 1.070 (1.022–1.121) | 0.004 | 1.010 (0.891–1.145) | 0.877 |
| HDL-C (mmol/L) | 1.19 (1.03–1.42) | 1.25 (1.06–1.48) | 0.000 | 0.619 (0.475–0.806) | 0.000 | 1.085 (0.685–1.718) | 0.729 |
| LDL-C (mmol/L) | 3.25 (±0.88) | 3.11 (2.62–3.69) | 0.038 | 1.101 (1.001–1.210) | 0.048 | 1.087 (0.763–1.548) | 0.645 |
| TSH (mIU/L) | 1.63 (1.09–2.35) | 1.61 (1.13–2.34) | 0.967 | 0.976 (0.924–1.031) | 0.387 | – | – |
| FT (pmol/L) | 11.2 (10.1–12.3) | 11.2 (10.2–12.3) | 0.679 | 0.983 (0.948–1.020) | 0.361 | – | – |
| FT (pmol/L) | 4.9 (4.6–5.4) | 5.0 (4.5–5.4) | 0.199 | 0.905 (0.809–1.013) | 0.083 | – | – |
| FPG (mmol/L) | 4.8 (4.4–5.3) | 4.7 (4.2–5.1) | 0.000 | 1.131 (1.063–1.204) | 0.000 | 0.989 (0.918–1.065) | 0.765 |
| UA (mmol/L) | 349 (291–414) | 336 (276–396) | 0.000 | 1.002 (1.001–1.003) | 0.000 | 1.000 (0.998–1.001) | 0.508 |
| Scr (umol/L) | 70 (59–78) | 66 (55–76) | 0.000 | 1.017 (1.011–1.023) | 0.000 | 1.000 (0.992–1.009) | 0.925 |
| ALT (U/L) | 24 (17–36) | 22 (16–34) | 0.004 | 1.002 (1.000–1.004) | 0.033 | 1.002 (0.996–1.007) | 0.550 |
| AST (U/L) | 25 (21–31) | 24 (20–30) | 0.002 | 1.003 (1,000–1.007) | 0.047 | 0.999 (0.991–1.008) | 0.857 |
| Smoking n (%) | 254 (37.7) | 1026 (26.7) | 0.000 | 1.659 (1.397–1.969) | 0.000 | 1.302 (1.060–1.599) | 0.012 |
| Alcohol n (%) | 307 (45.5) | 1344 (35.0) | 0.000 | 1.554 (1.317–1.833) | 0.000 | 1.192 (0.975–1.457) | 0.086 |
| TNs n (%) | 274 (40.7) | 1303 (33.9) | 0.001 | 1.334 (1.128–1.577) | 0.001 | 1.206 (1.006–1.445) | 0.043 |
| MS n (%) | 139 (20.6) | 478 (12.4) | 0.000 | 1.827 (1.482–2.254) | 0.000 | 1.312 (1.013–1.700) | 0.040 |
| ALT – alanine aminotransferase; AST – aspartate aminotransferase; BMI – body mass index; FPG – fasting plasma glucose; FT – free triiodothyronine; FT – free thyroxine; HDL-C – high-density lipoprotein cholesterol; LDL-C – low-density lipoprotein cholesterol; MS – metabolic syndrome; OR – odds ratio; Scr – serum creatinine; TC – total cholesterol; TG – triglyceride; TNs – thyroid nodules; TSH – thyrotropin; UA – uric acid. | |||||||