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18 January 2021 : Clinical Research  

Urinary Alpha1-Microglobulin: A New Predictor for In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction

Hehe Cui1ABCDE, Xiao Zhang2CDE, Xiaosong Ding1ABE, Li Zhou1ADE, Siwen Liang1AF, Hui Qiu1CF, Hongwei Li1ABFG, Hui Chen1ADEG*

DOI: 10.12659/MSM.927958

Med Sci Monit 2021; 27:e927958

Table 1 Basic demographic, clinical, and laboratory factors of the tertile subgroups of the admission UA1MG.

CharacteristicsTertile 1, n=623<0.77Tertile 2, n=6110.77–1.89Tertile 3, n=620>1.89p1 valuep2 value
Age, years60.92±11.7462.69±12.8866.57±12.77<0.001<0.001
Male gender, n (%)457 (73.4)475 (77.7)476 (76.8)0.1650.164
PPCI, n (%)368 (62.0)362 (63.3)306 (58.3)0.2160.211
Medical histories
 CHD, n (%)181 (29.2)171 (28.1)186 (30.2)0.7280.700
 Hypertension, n (%)342 (55.0)354 (58.0)397 (64.7)0.0020.001
 DM, n (%)140 (22.5)170 (27.9)223 (36.1)<0.001<0.001
 Dyslipidemia, n (%)274 (44.1)278 (45.6)264 (42.9)0.6310.672
 Smoke, n (%)327 (52.7)326 (53.4)286 (46.4)0.2590.044
SBP, mmHg124.43±19.90125.16±21.91123.70±22.330.4930.550
DBP, mmHg73.16±12.6672.91±12.6672.45±13.240.6220.336
HR, bpm72.26±12.8475.90±15.3678.40±16.99<0.001<0.001
Killip ≥III n (%)20 (3.2)39 (6.4)83 (13.7)<0.001<0.001
Laboratory index
 WBC, ×10/L8.79±2.959.17±3.099.94±3.30<0.001<0.001
 Neutrophil, ×10/L5.92 (4.26–7.76)6.32 (4.82–8.32)6.99 (5.47–9.44)<0.001<0.001
 Hemoglobin, g/L140.92±17.69140.37±19.00136.09±20.84<0.001<0.001
 platelets, ×10/L230.45±62.67227.02±67.89220.20±76.320.0290.009
 RDW, %12.7 (12.0–13.7)12.7 (12.0–13.6)12.9 (12.1–13.8)0.1200.286
 PDW, %13.58±2.6813.74±2.8514.17±2.79<0.001<0.001
 Glucose, mmol/L7.3 (6.2–9.2)7.91 (6.47–10.80)8.62 (6.95–12.54)<0.001<0.001
 Creatinine, μmol/L76.8 (66.9–86.3)80.4 (70.8–90.4)87.1 (74.4–103.0)<0.001<0.001
 ALT, U/L23.0 (16.0–33.0)24.0 (17.0–36.0)25.0 (17.0–39.0)0.0470.006
 Albumin, g/L39.81±3.8439.35±4.0238.26±4.79<0.001<0.001
 T-BIL, μmol/L11.4 (8.6–15.3)12.4 (9.20–17.0)12.8 (9.2–18.3)<0.001<0.001
 TC, mmol/L4.57±0.994.43±1.044.39±1.070.010<0.001
 LDL-C, mmol/L2.69±0.732.57±0.762.54±0.790.0020.001
 HDL-C, mmol/L1.02 (0.9–1.17)1.03 (0.88–1.21)1.01 (0.88–1.21)0.5380.487
 TG, mmol/L1.42 (1.06–1.99)1.38 (0.99–2.12)1.30 (0.99–1.86)0.0350.012
 hsCRP, mg/dL4.2 (1.8–10.9)6.7 (2.3–16.0)13.6 (4.3–30.5)<0.001<0.001
 HbA1c, %6.26±1.376.45±1.476.74±1.67<0.001<0.001
Categorical variable was presented as percentage and numeric variable was presented as mean±standard deviation or the median (interquartile range). P1 value was obtained from comparing three subgroups. P2 value was obtained from comparing the tertile 3 subgroup with the tertile 1 subgroup. PPCI – primary percutaneous coronary intervention; CHD – coronary heart disease; DM – diabetic mellitus; DBP – diastolic blood pressure; SBP – systolic blood pressure; HR – heart rate; WBC – white blood cells; RDW – red blood cell distribution width; PDW – platelet distribution width; ALT – alanine aminotransferase; TG – triglyceride; T-BIL – total bilirubin; TC – total cholesterol; HDL-C – high-density-lipoprotein cholesterol; LDL-C – low-density-lipoprotein cholesterol; hs-CRP – high sensitive C-reactivity protein; HbA1c – glycated hemoglobin A1c; UA1MG – urinary alpha1-microglobulin.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750