18 January 2021 : Clinical Research
Urinary Alpha1-Microglobulin: A New Predictor for In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction
Hehe Cui1ABCDE, Xiao Zhang2CDE, Xiaosong Ding1ABE, Li Zhou1ADE, Siwen Liang1AF, Hui Qiu1CF, Hongwei Li1ABFG, Hui Chen1ADEG*DOI: 10.12659/MSM.927958
Med Sci Monit 2021; 27:e927958
Table 2 In-hospital outcomes, myocardial injuries, and left ventricular function of STEMI patients based on the tertiles of UA1MG.
| Characteristics | Tertile 1, n=623<0.77 | Tertile 2, n=6110.77–1.89 | Tertile 3, n=620>1.89 | p1 value | p2 value |
|---|---|---|---|---|---|
| In-hospital death, % | 6 (1.0) | 10 (1.7) | 27 (4.4) | <0.001 | <0.001 |
| Cardiac death, % | 4 (0.6) | 10 (1.7) | 19 (3.1) | 0.005 | 0.001 |
| MACE, % | 29 (4.7) | 31 (5.1) | 53 (8.6) | 0.007 | 0.005 |
| Cardiac markers | |||||
| Peak NTproBNP, pg/mL | 1164.0 (503.0–2706.0) | 1613.0 (701.0–3907.0) | 3825.0 (1639.5–9982.0) | <0.001 | <0.001 |
| Peak CK-MB, ng/mL | 74.7 (11.9–202.0) | 95.9 (17.7–215.0) | 100.0 (21.1–273.8) | 0.001 | 0.004 |
| Peak cTnI, ng/mL | 10.9 (2.5–28.7) | 15.1 (4.0–37.7) | 23.9 (7.2–50.0) | <0.001 | <0.001 |
| LVEF | 0.59±0.09 | 0.57±0.09 | 0.54±0.10 | <0.001 | <0.001 |
| Categorical variable was presented as percentage and numeric variable was presented as mean±standard deviation or the median (interquartile range). P1 value was obtained from comparing three subgroups. P2 value was obtained from comparing the tertile 3 subgroup with the tertile 1 subgroup. MACE – major adverse cardiac events; CK-MB – creatine kinase MB; cTnI – cardiac troponin I; NT-proBNP – N-terminal pro-B-type Natriuretic Peptide; LVEF – left ventricular ejection fraction; UA1MG – urinary alpha1-microglobulin. | |||||