High Expression of the Component 3a Receptor 1 (C3AR1) Gene in Stomach Adenocarcinomas Infers a Poor Prognosis and High Immune-Infiltration Levels

Haibo Yang; Lin Li; Xiaoyu Liu; Yu Zhao

doi:10.12659/MSM.927977

04 February 2021 : Database Analysis

High Expression of the Component 3a Receptor 1 (C3AR1) Gene in Stomach Adenocarcinomas Infers a Poor Prognosis and High Immune-Infiltration Levels

Haibo Yang^1ABCDF, Lin Li^2BD, Xiaoyu Liu^1B, Yu Zhao^1ADG*

DOI: 10.12659/MSM.927977

Med Sci Monit 2021; 27:e927977

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Table 2 Correlation between C3AR1 and immune markers in STAD by TIMER and GEPIA database.

Description	Gene markers	TIMER		GEPIA
Description	Gene markers	r	P-value	r	P-value
CD8+T Cell	CD8A	0.552	^***	0.57	^***
CD8+T Cell	CD8B	0.342	^***	0.37	^***
B Cell	CD19	0.285	^***	0.24	^***
B Cell	CD79A	0.373	^***	0.34	^***
Monocyte	CD86	0.909	^***	0.92	^***
Monocyte	CD115(CSF1R)	0.902	^***	0.9	^***
TAMs	CCL2	0.522	^***	0.55	^***
	CD68	0.661	^***	0.73	^***
	IL10	0.704	^***	0.75	^***
M1 macrophage	INOS(NOS2)	0.113	^*	0.15	^**
	IRF5	0.342	^***	0.4	^***
	COX2(PTGS2)	0.074	.	0.17	^***
M2 macrophage	CD163	0.903	^***	0.83	^***
	VSIG4	0.865	^***	0.87	^***
	MS4A4A	0.923	^***	0.93	^***
Dendritic Cells	HLA-DPB1	0.661	^***	0.69	^***
	HLA-DQB1	0.515	^***	0.4	^***
	HLA-DRA	0.698	^***	0.71	^***
	HLA-DPA1	0.696	^***	0.7	^***
	BDCA-1(CD1C)	0.46	^***	0.45	^***
	BDCA-4(NRP1)	0.587	^***	0.64	^***
	CD11c (ITGAX)	0.814	^***	0.8	^***
NK Cells	KIR2DL1	0.366	^***	0.37	^***
	KIR2DL3	0.326	^***	0.46	^***
	KIR2DL4	0.299	^***	0.3	^***
	KIR3DL1	0.286	^***	0.35	^***
	KIR3DL2	0.31	^***	0.37	^***
	KIR3DL3	0.077	.	0.048	.
	KID2DS4	0.253	^***	–	–
T Cell (general)	CD3D	0.566	^***	0.55	^***
	CD3E	0.53	^***	0.54	^***
	CD2	0.652	^***	0.67	^***
Th1	T-bet (TBX21)	0.563	^***	0.58	^***
	STAT4	0.624	^***	0.62	^***
	STAT1	0.343	^***	0.45	^***
	IFN-γ (IFNG)	0.423	^***	0.45	^***
	TNF-α (TNF)	0.279	^***	0.33	^***
Th2	GATA3	0.417	^***	0.44	^***
	STAT6	0.019	.	0.016	^**
	STAT5A	0.465	^***	0.55	^***
	IL13	0.133	^**	0.19	^***
Tfh	BCL6	0.3	^***	0.4	^***
Tfh	IL21	0.435	^***	0.49	^***
Th17	STAT3	0.365	^***	0.45	^***
Th17	IL17A	0.007	.	0.031	.
Treg cells	FOXP3	0.562	^***	0.59	^***
	CCR8	0.665	^***	0.71	^***
	STAT5B	0.346	^***	0.48	^***
	TGF-β	0.453	^***	0.5	^***
Neutrophils	CD66B	0.064	.	0.069	.
	CD11b	0.784	^***	0.77	^***
	CCR7	0.492	^***	0.51	^***
Exhaustion T cells	TIM-3 (HAVCR2)	0.907	^***	0.92	^***
	TIGIT	0.57	^***	0.6	^***
	GZMA	0.553	^***	0.56	^***
	LAG-3	0.501	^***	0.49	^***
	CTLA4	0.478	^***	0.54	^***
	PD-1 (PDCD1)	0.467	^***	0.49	^***
TAMs – tumor-associated macrophages; NK cells – natural killer cells; Th1, Th2, Tfh, Th17 – helper T cell subtypes. ≥0.05, ^* ^ ^*

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High Expression of the Component 3a Receptor 1 (C3AR1) Gene in Stomach Adenocarcinomas Infers a Poor Prognosis and High Immune-Infiltration Levels

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