11 October 2020: Clinical Research
Prognostic Value of Surgical Site Infection in Patients After Radical Colorectal Cancer Resection
Yu Tang BEF , Ruizhi Zhang CF , Wenchang Yang BD , Wei Li AG , Kaixiong Tao AG*DOI: 10.12659/MSM.928054
Med Sci Monit 2020; 26:e928054
Table 4 Prognostic analysis on 3-year DFS in patients with colorectal cancer.
| Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | ||
| Incisional SSI | 0.581 (0.213–1.588) | 0.290 | |||
| Organ/space SSI | 1.492 (0.603–3.693) | 0.387 | |||
| Incisional+organ/space SSI | 2.794 (1.624–4.806) | 4.000 (1.459–10.964) | 0.007 | ||
| Sex | F | Ref. | |||
| M | 1.006 (0.669–1.514) | 0.977 | |||
| Age ≥60 (year) | 1.596 (1.073–2.376) | 0.021 | 1.880 (1.207–2.929) | 0.005 | |
| Tumor location | Colon | Ref. | |||
| Rectum | 0.786 (0.524–1.177) | 0.242 | |||
| Tumor size (cm) | Ref. | ||||
| ≥5 | 1.297 (0.869–1.935) | 0.203 | |||
| Tumor differentiation | poor | Ref. | Ref. | ||
| high | 0.568 (0.332–0.971) | 0.039 | 0.932 (0.506–1.718) | 0.823 | |
| Lymph node involvement | 3.280 (2.141–5.025) | 2.968 (1.818–4.847) | |||
| Depth of tumor | T1–T2 | Ref. | Ref. | ||
| T3–T4 | 4.796 (1.950–11.796) | 3.789 (1.166–12.307) | 0.027 | ||
| Operative approach | open | Ref. | Ref. | ||
| Lap | 0.553 (0.372–0.823) | 0.003 | 0.693 (0.447–1.074) | 0.101 | |
| Anastomotic leakage | 1.839 (1.076–3.144) | 0.026 | 0.557 (0.178–1.743) | 0.315 | |
| Adjuvant chemotherapy | 0.796 (0.535–1.183) | 0.259 | |||
| Preoperative obstruction | 1.277 (0.837–1.948) | 0.256 | |||
| Vascular invasion | 1.631 (1.047–2.541) | 0.031 | 0.817 (0.482–1.386) | 0.454 | |
| Perineural invasion | 1.860 (1.219–2.838) | 0.004 | 1.372 (0.858–2.192) | 0.186 | |
| Blood transfusion | 1.493 (0.990–2.252) | 0.056 | |||
| Preoperative CEA (ng/ml) | Ref. | Ref. | |||
| ≥5 | 1.545 (1.037–2.304) | 0.033 | 1.079 (0.684–1.701) | 0.774 | |
| Preoperative CA125 (ng/ml) | Ref. | ||||
| ≥35 | 2.271 (1.289–4.003) | 0.005 | 1.660 (0.873–3.159) | 0.122 | |
| Preoperative CA199 (ng/ml) | Ref. | ||||
| ≥37 | 1.733 (1.050–2.861) | 0.031 | 1.088 (0.622–1.901) | 0.768 | |
| HR – hazard ratio; CI – confidence interval; SSI – surgical site infection; F – Female; M – Male; Lap – laparoscopic. | |||||