11 October 2020: Clinical Research
Prognostic Value of Surgical Site Infection in Patients After Radical Colorectal Cancer Resection
Yu Tang BEF , Ruizhi Zhang CF , Wenchang Yang BD , Wei Li AG , Kaixiong Tao AG*DOI: 10.12659/MSM.928054
Med Sci Monit 2020; 26:e928054
Table 5 Prognostic analysis on OS in patients with colorectal cancer.
| Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | ||
| Incisional SSI | 0.598 (0.219–1.635) | 0.316 | |||
| Organ/space SSI | 1.222 (0.446–3.351) | 0.696 | |||
| Incisional+organ/space SSI | 3.164 (1.862–5.377) | 3.694 (1.346–10.138) | 0.011 | ||
| Sex | F | Ref. | |||
| M | 1.081 (0.719–1.626) | 0.708 | |||
| Age ≥60 (year) | 2.026 (1.352–3.036) | 0.001 | 1.941 (1.197–3.147) | 0.007 | |
| Tumor location | Colon | Ref. | |||
| Rectum | 0.841 (0.561–1.260) | 0.402 | |||
| Tumor size (cm) | Ref. | ||||
| ≥5 | 1.274 (0.850–1.910) | 0.242 | |||
| Tumor differentiation | poor | Ref. | |||
| high | 0.637 (0.367–1.105) | 0.109 | |||
| Lymph node involvement | 2.935 (1.921–4.484) | 2.632 (1.625–4.262) | |||
| Depth of tumor | T1–T2 | Ref. | Ref. | ||
| T3–T4 | 3.947 (1.727–9.021) | 0.001 | 2.961 (1.043–8.405) | 0.041 | |
| Operative approach | open | Ref. | Ref. | ||
| Lap | 0.537 (0.361–0.800) | 0.002 | 0.681 (0.439–1.057) | 0.087 | |
| Anastomotic leakage | 1.937 (1.133–3.312) | 0.016 | 0.662 (0.213–2.055) | 0.475 | |
| Adjuvant chemotherapy | 0.634 (0.426–0.945) | 0.025 | 0.598 (0.372–0.964) | 0.035 | |
| Preoperative obstruction | 1.184 (0.770–1.821) | 0.442 | |||
| Vascular invasion | 1.780 (1.140–2.781) | 0.011 | 0.943 (0.547–1.625) | 0.832 | |
| Perineural invasion | 2.032 (1.326–3.112) | 0.001 | 1.510 (0.936–2.434) | 0.091 | |
| Blood transfusion | 1.306 (0.858–1.987) | 0.213 | |||
| Preoperative CEA (ng/ml) | Ref. | Ref. | |||
| ≥5 | 1.711 (1.147–2.553) | 0.009 | 1.129 (0.716–2.553) | 0.603 | |
| Preoperative CA125 (ng/ml) | Ref. | Ref. | |||
| ≥35 | 3.106 (1.811–5.326) | 1.892 (1.027–3.485) | 0.041 | ||
| Preoperative CA199 (ng/ml) | Ref. | Ref. | |||
| ≥37 | 2.001 (1.234–3.246) | 0.005 | 1.381 (0.803–2.377) | 0.243 | |
| SSI –surgical site infection; HR – hazard ratio; CI – confidence interval; F – Female; M – Male; Lap – laparoscopic. | |||||