21 December 2020: Clinical Research
Urinary Liver-Type Fatty Acid-Binding Protein Predicts Residual Renal Function Decline in Patients on Peritoneal Dialysis
Kenta Torigoe 1ABCDEF , Kumiko Muta 1ABCDEF* , Kiyokazu Tsuji 1B , Ayuko Yamashita 1B , Yuki Ota 1B , Mineaki Kitamura 1DE , Hiroshi Mukae 2G , Tomoya Nishino 1ADEGDOI: 10.12659/MSM.928236
Med Sci Monit 2020; 26:e928236
Table 1 Characteristics of patients on peritoneal dialysis.
| Characteristic | Value |
|---|---|
| Age (y) | 61.1±12.9 |
| Duration of PD (mo) | 13 (11–24) |
| Sex (Male: Female) | 20: 15 |
| BMI (kg/m) | 22.6 (20.2–25.4) |
| Systolic BP (mmHg) | 129.9±21.9 |
| Diastolic BP (mmHg) | 75.2±15.2 |
| Primary disease of ESRD (%) | |
| Chronic glomerulonephritis | 25.7 |
| Diabetic kidney disease | 14.3 |
| Nephrosclerosis | 34.3 |
| Other | 25.7 |
| Comorbidity | |
| Diabetes mellitus (%) | 25.7 |
| Charlson Comorbidity Index | 3 (2–3) |
| ARB/ACE-I (%) | 65.7 |
| CCB (%) | 62.9 |
| Diuretic (%) | 82.9 |
| Statin (%) | 28.6 |
| CAPD: APD | 24: 11 |
| Hb (g/dL) | 11.1±1.5 |
| Alb (g/dL) | 3.2±0.3 |
| Corrected Ca (mg/dL) | 9.2±0.6 |
| P (mg/dL) | 5.1 (4.3–5.6) |
| Intact PTH (pg/mL) | 167.6 (89.4–260.2) |
| Total cholesterol (mg/dL) | 189.7±34.2 |
| HbA1c (%) | 5.4 (5.1–5.7) |
| CRP (mg/dL) | 0.06 (0.03–0.21) |
| Urinary volume (mL/day) | 1,500 (1,120–1,700) |
| Residual GFR (mL/min) | 4.12 (2.59–6.61) |
| Peritoneal Kt/V | 1.04±0.38 |
| Renal Kt/V | 0.85 (0.64–1.45) |
| Total Kt/V | 2.00 (1.67–2.49) |
| 4-h D/P Cr | 0.61 (0.56–0.68) |
| nPCR | 0.87±0.18 |
| Urinary protein (g/day) | 0.51 (0.26–0.76) |
| Urinary protein (mg/dL Cr) | 0.82 (0.46–1.27) |
| Urinary L-FABP (μg/day) | 82.8 (59.9–125.9) |
| Urinary L-FABP (μg/g) | 70.2±37.4 |
| Renal Kt/V decline rate (/y) | 0.29 (0.05–0.48) |
| Duration of follow-up (mo) | 11.0 (11.0–12.0) |
| Alb (g/dL) | 3.2±0.3 |
| ACE-I – angiotensin converting enzyme inhibitor; Alb – albumin; APD – automated peritoneal dialysis; ARB – angiotensin II receptor blocker; BMI – body mass index; BP – blood pressure; Ca – calcium; CAPD – continuous ambulatory peritoneal dialysis; CCB – calcium channel blocker; Cr – creatinine; CRP – C-reactive protein; D/P – dialysate/plasma creatinine; GFR – glomerular filtration rate; Hb – hemoglobin; nPCR – normalized protein catabolism rate; L-FABP – L-type fatty acid-binding protein; P – phosphorus; PD – peritoneal dialysis; PTH – parathyroid hormone. | |