20 March 2021 : Database Analysis
Potential Target Genes in the Development of Atrial Fibrillation: A Comprehensive Bioinformatics Analysis
Liang Liu1CE, Yun Yu1BC, Long-long Hu1D, Quan-bin Dong1D, Feng Hu1D, Ling-juan Zhu1D, Qian Liang1D, Ling-ling Yu1B, Hui-hui Bao1A, Xiao-shu Cheng1A*DOI: 10.12659/MSM.928366
Med Sci Monit 2021; 27:e928366
Table 2 Significantly enriched pathways in AF.
| Rank | Pathway | Genes |
|---|---|---|
| 1 | infection | C1QA; C1QB; FPR2; HLA-DPB1; FCGR3B; C1QC; HLA-DQA1; HLA-DRA |
| 2 | Intestinal immune network for IgA production | CXCR4; TNFRSF17; ITGA4; HLA-DPB1; HLA-DQA1; HLA-DRA; CD28 |
| 3 | Chemokine signaling pathway | HRAS; PPBP; RAC2; GNB2; ARRB2; CXCR4; PREX1; HCK; CCR2; CCL19; CXCR2 |
| 4 | Systemic lupus erythematosus | C1QA; C1QB; HLA-DPB1; FCGR3B; HIST1H3G; C1QC; HLA-DQA1; HLA-DRA; CD28 |
| 5 | Asthma | FCER1G; MS4A2; HLA-DPB1; HLA-DQA1; HLA-DRA |
| 6 | Osteoclast differentiation | CYBA; JUND; LILRA6; SPI1; FHL2; FCGR3B; BLNK; TYROBP |
| 7 | Leishmaniasis | CYBA; ITGA4; HLA-DPB1; FCGR3B; HLA-DQA1; HLA-DRA |
| 8 | Cytokine-cytokine receptor interaction | IL1R2; PPBP; CXCR4; CCR2; CCL19; TNFRSF17; CSF3R; CXCR2; CSF2RA; CD27 |
| 9 | Natural killer cell mediated cytotoxicity | HRAS; RAC2; FCER1G; FCGR3B; KLRD1; TYROBP; HCST |
| 10 | Hematopoietic cell lineage | IL1R2; CSF3R; ITGA4; CD1E; CSF2RA; HLA-DRA |
| 11 | Viral myocarditis | RAC2; HLA-DPB1; HLA-DQA1; HLA-DRA; CD28 |
| 12 | Graft-versus-host disease | HLA-DPB1; HLA-DQA1; HLA-DRA; CD28 |
| 13 | Cell adhesion molecules (CAMs) | SELL; ITGA4; HLA-DPB1; JAM3; HLA-DQA1; HLA-DRA; CD28 |
| 14 | Allograft rejection | HLA-DPB1; HLA-DQA1; HLA-DRA; CD28 |
| 15 | Phagosome | CYBA; CORO1A; COMP; HLA-DPB1; FCGR3B; HLA-DQA1; HLA-DRA |
| 16 | Type I diabetes mellitus | HLA-DPB1; HLA-DQA1; HLA-DRA; CD28 |
| 17 | Leukocyte transendothelial migration | CYBA; RAC2; CXCR4; ITGA4; JAM3; CTNNB1 |
| 18 | Autoimmune thyroid disease | HLA-DPB1; HLA-DQA1; HLA-DRA; CD28 |