29 May 2021 : Laboratory Research
Silencing Ribosomal Protein L22 Promotes Proliferation and Migration, and Inhibits Apoptosis of Gastric Cancer Cells by Regulating the Murine Double Minute 2-Protein 53 (MDM2-p53) Signaling Pathway
Zhenqing Sun1ABCE, Zhigang Qiu1ABCE, Zhengkun Wang1DE, Honghui Chi2DE, Peipei Shan3CE*DOI: 10.12659/MSM.928375
Med Sci Monit 2021; 27:e928375
Table 2 Correlation between the expression of RPL22 and clinicopathological features of gastric cancer patients.
| Parameter | Number (N=40) | RPL22 mRNA expression | P value |
|---|---|---|---|
| Age (years) | |||
| <50 | 7 | 0.6618±0.1622 | 0.9766 |
| ≥50 | 33 | 0.6700±0.1226 | |
| Gender | |||
| Male | 22 | 0.7084±0.1370 | 0.6191 |
| Female | 18 | 0.6199±0.0994 | |
| Stage | |||
| Early stage | 29 | 0.7370±0.0692 | 0.0372* |
| Advanced stage | 11 | 0.4883±0.0347 | |
| Lymphatic metastasis | |||
| No | 23 | 0.7301±0.0450 | 0.0212* |
| Yes | 17 | 0.5723±0.0501 | |
| Tumor position | |||
| Cardia | 6 | 0.4996±0.0089 | 0.7469 |
| Gastric fundus | 5 | 0.6793±0.1779 | |
| Antrum | 22 | 0.7101±0.1096 | |
| Gastric angle | 7 | 0.7046±0.0686 | |
| Degree of histological type | |||
| Good | 9 | 0.6633±0.1669 | 0.9995 |
| Moderate | 6 | 0.6688±0.0892 | |
| Poor | 25 | 0.6704±0.1253 | |
| RPL22 – ribosomal proteins L22; * represented significantly different at | |||