03 March 2021 : Animal Research
A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model
Sen Ling Feng1ACE, Jing Zhang2BCEF, Hongliu Jin1BC, Wen Ting Zhu1BC, Zhongwen Yuan1ABCDEFG*DOI: 10.12659/MSM.928402
Med Sci Monit 2021; 27:e928402
Table 4 The node characteristic parameters of the main targets in the compound-target network.
| Target | Target name | Degree | Betweenness | Closeness |
|---|---|---|---|---|
| PTGS2 | Prostaglandin G/H synthase 2 | 17 | 0.240087 | 0.525822 |
| NOS3 | Nitric oxide synthase, endothelial | 6 | 0.021565 | 0.435798 |
| PPARG | Peroxisome proliferator activated receptor gamma | 5 | 0.009116 | 0.425856 |
| DPP4 | Dipeptidyl peptidase IV | 5 | 0.020751 | 0.432432 |
| BCL2 | Apoptosis regulator Bcl-2 | 4 | 0.006814 | 0.413284 |
| TNF | Tumor necrosis factor | 4 | 0.011948 | 0.410256 |
| PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform | 4 | 0.008965 | 0.416357 |
| F10 | Coagulation factor X | 4 | 0.028392 | 0.422642 |