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30 January 2021: Clinical Research

Evaluation of Reduced-Dose Decitabine and Azacitidine for Treating Myelodysplastic Syndromes: A Retrospective Study

Naibo Hu 12DE , Tiejun Qin 1B , Xiaoyan Du 3C , Bingyi Wang 3DE , Xiaoyun Wang 3E , Zefeng Xu 1DF , Lijuan Pan 1F , Shiqiang Qu 1DF , Zhijian Xiao 1A*

DOI: 10.12659/MSM.928454

Med Sci Monit 2021; 27:e928454

Table 5 Univariate and multivariate regression analysis of the factors for overall responses.

IndicatorsUnivariateMultivariate
OR (95% Cl)P valueOR (95% Cl)P value
 Azacitidineref
 Decitabine2.291 (1.097–4.881)0.029* 2.580 (1.130–6.055)0.026*
1.009 (0.983–1.036)0.4791.003 (0.971–1.036)0.848
 Male1.227 (0.636–2.366)0.5401.117 (0.517–2.396)0.776
 Femaleref
 MDS-EB12.261 (0.862–6.102)0.0991.222 (0.302–4.913)0.776
 MDS-EB21.719 (0.670–4.527)0.2620.945 (0.211–4.246)0.941
 MDS-MLD/RS/Uref
 Goodref
 Intermediate0.619 (0.293–1.301)0.2061.037 (0.383–2.858)0.943
 Poor0.703 (0.312–1.586)0.3921.210 (0.382–3.910)0.747
 Intermediate-1ref
 Intermediate-20.800 (0.391–1.628)0.5380.598 (0.214–1.643)0.321
 High0.563 (0.234–1.338)0.1940.388 (0.086–1.644)0.205
ref
 ≥52.009 (0.950–4.300)0.0692.384 (0.754–7.648)0.137
1.283 (0.442–3.766)0.6462.214 (0.465–10.718)0.317
RBC0.804 (0.483–1.328)0.3930.586 (0.211–1.548)0.289
Hb1.002 (0.987–1.018)0.8151.016 (0.986–1.050)0.310
ANC0.737 (0.567–0.913)0.012* 0.728 (0.541–0.916)0.019*
PLT1 (0.996–1.004)0.8891 (0.995–1.004)0.914
*
ANC – absolute neutrophil count; BM – bone marrow; Hb – hemoglobin; IPSS – International Prognostic Scoring System; MDS-EB1 – MDS with excess blasts 1; MDS-EB2 – MDS with excess blasts 2; MDS-MLD/RS/U – multilineage dysplasia/ring sideroblasts/unclassifiable; PLT – platelets; ref – this variable was used as a control in the statistical analysis; RBC – red blood cells.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750