30 January 2021>: Clinical Research
Evaluation of Reduced-Dose Decitabine and Azacitidine for Treating Myelodysplastic Syndromes: A Retrospective Study
Naibo Hu 12DE , Tiejun Qin 1B , Xiaoyan Du 3C , Bingyi Wang 3DE , Xiaoyun Wang 3E , Zefeng Xu 1DF , Lijuan Pan 1F , Shiqiang Qu 1DF , Zhijian Xiao 1A*DOI: 10.12659/MSM.928454
Med Sci Monit 2021; 27:e928454
Table 5 Univariate and multivariate regression analysis of the factors for overall responses.
Indicators | Univariate | Multivariate | ||
---|---|---|---|---|
OR (95% Cl) | P value | OR (95% Cl) | P value | |
Azacitidine | ref | |||
Decitabine | 2.291 (1.097–4.881) | 0.029* | 2.580 (1.130–6.055) | 0.026* |
1.009 (0.983–1.036) | 0.479 | 1.003 (0.971–1.036) | 0.848 | |
Male | 1.227 (0.636–2.366) | 0.540 | 1.117 (0.517–2.396) | 0.776 |
Female | ref | |||
MDS-EB1 | 2.261 (0.862–6.102) | 0.099 | 1.222 (0.302–4.913) | 0.776 |
MDS-EB2 | 1.719 (0.670–4.527) | 0.262 | 0.945 (0.211–4.246) | 0.941 |
MDS-MLD/RS/U | ref | |||
Good | ref | |||
Intermediate | 0.619 (0.293–1.301) | 0.206 | 1.037 (0.383–2.858) | 0.943 |
Poor | 0.703 (0.312–1.586) | 0.392 | 1.210 (0.382–3.910) | 0.747 |
Intermediate-1 | ref | |||
Intermediate-2 | 0.800 (0.391–1.628) | 0.538 | 0.598 (0.214–1.643) | 0.321 |
High | 0.563 (0.234–1.338) | 0.194 | 0.388 (0.086–1.644) | 0.205 |
ref | ||||
≥5 | 2.009 (0.950–4.300) | 0.069 | 2.384 (0.754–7.648) | 0.137 |
1.283 (0.442–3.766) | 0.646 | 2.214 (0.465–10.718) | 0.317 | |
RBC | 0.804 (0.483–1.328) | 0.393 | 0.586 (0.211–1.548) | 0.289 |
Hb | 1.002 (0.987–1.018) | 0.815 | 1.016 (0.986–1.050) | 0.310 |
ANC | 0.737 (0.567–0.913) | 0.012* | 0.728 (0.541–0.916) | 0.019* |
PLT | 1 (0.996–1.004) | 0.889 | 1 (0.995–1.004) | 0.914 |
* ANC – absolute neutrophil count; BM – bone marrow; Hb – hemoglobin; IPSS – International Prognostic Scoring System; MDS-EB1 – MDS with excess blasts 1; MDS-EB2 – MDS with excess blasts 2; MDS-MLD/RS/U – multilineage dysplasia/ring sideroblasts/unclassifiable; PLT – platelets; ref – this variable was used as a control in the statistical analysis; RBC – red blood cells. |