14 January 2021: Clinical Research
Comparison of Rocuronium with Succinylcholine for Rapid Sequence Induction Intubation in the Emergency Department: A Retrospective Study at a Single Center in China
Gui Li 1ABF , Lin Cheng 2DEF* , Jianke Wang 1ADFDOI: 10.12659/MSM.928462
Med Sci Monit 2021; 27:e928462
Table 1 Demographical, clinical, and anesthetic conditions of the enrolled patients at the Emergency Department.
| Characteristic | Groups | Comparison | ||
|---|---|---|---|---|
| SY | RM | |||
| Neuromuscular blocking agent used | Succinylcholine | Rocuronium | ||
| Patients included in analysis | 141 | 126 | P value | |
| Sex | Male | 95 (67) | 73 (58) | 0.128 |
| Female | 46 (33) | 53 (42) | ||
| Age (y) | Minimum | 18 | 18 | 0.344 |
| Maximum | 64 | 63 | ||
| Mean±SD | 51.15±11.41 | 52.41±10.19 | ||
| Body mass index (kg/m) | 24.12±2.22 | 24.41±1.45 | 0.213 | |
| Reason for intubation | Shock | 18 (13) | 17 (13) | 0.998 |
| Trauma | 22 (16) | 21 (17) | ||
| Coma due to neurological disease | 37 (26) | 33 (26) | ||
| Coma due to poisoning | 31 (22) | 25 (20) | ||
| Overdoses | 17 (12) | 16 (13) | ||
| Dyspnea | 16 (11) | 14 (11) | ||
| Glasgow Coma Scale score | Minimum | 3 | 3 | 0.828 |
| Maximum | 7 | 7 | ||
| Mean±SD | 5.45±1.45 | 5.41±1.56 | ||
| Heart rate (beats/min) | 105±11 | 102±15 | 0.062 | |
| Breaths/min | 24±4 | 25±5 | 0.071 | |
| Arterial diastolic pressure (mmHg) | 115 (82) | 101 (80) | 0.876 | |
| 26 (18) | 25 (20) | |||
| Arterial systolic pressure (mmHg) | 109 (77) | 88 (70) | 0.211 | |
| ≥140 | 32 (23) | 38 (30) | ||
| % Peripheral oxygen saturation | 94.51±4.55 | 94.01±4.01 | 0.344 | |
| Total etomidate administered (mg) | 22.12±4.15 (n=115) | 21.15±4.11 (n=107) | 0.057 | |
| Total ketamine administered (mg) | 39±4 (n=26) | 41±5 (n=19) | 0.143 | |
| Total propofol administered (mg) | 527±21 | 531±25 | 0.197 | |
| Cancer history | 9 (6) | 2 (2) | 0.065 | |
| Cardiac disease history | 15 (11) | 7 (6) | 0.181 | |
| Renal disease history | 4 (3) | 11 (9) | 0.059 | |
| Patient position during intubation | Lying on a stretcher | 87 (62) | 79 (63) | 0.897 |
| Lying on a bed | 54 (38) | 47 (37) | ||
| Descriptive data are demonstrated as frequency (percentage) and numerical and ordinal data are demonstrated as mean±SD. Two-tailed unpaired test was performed for numerical and ordinal data and the Fischer exact test was performed for descriptive data. All results were considered significant if the value was less than 0.05. | ||||