Fractional Exhaled Nitric Oxide (FeNO) Integrating Airway Hyperresponsiveness (AHR) Examination Promotes Etiologic Diagnosis and Treatment for Children with Chronic Cough

Haiyan Zhu; Chuangli Hao; Xingmei Yu; Rongrong Zhang; Wendi Zhou; Xingzhen Sun; Yufang Yuan; Zhaofang Tian

doi:10.12659/MSM.928502

22 February 2021 : Clinical Research

Fractional Exhaled Nitric Oxide (FeNO) Integrating Airway Hyperresponsiveness (AHR) Examination Promotes Etiologic Diagnosis and Treatment for Children with Chronic Cough

Haiyan Zhu^1BCDEF, Chuangli Hao^2BCDE, Xingmei Yu^2BCDF, Rongrong Zhang^1BCD, Wendi Zhou^1BCF, Xingzhen Sun^1BCF, Yufang Yuan^1BCF, Zhaofang Tian^1ABDEG*

DOI: 10.12659/MSM.928502

Med Sci Monit 2021; 27:e928502

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Table 2 Comparative analysis of pulmonary function indexes in children with chronic cough for the different etiologies (χ±s).

Parameters	CVA group (n=45)	UACS group (n=53)	PIC group (n=20)	F	P
FEV1% pred	93±14	99±10	94±10	1.918	0.136
FEV1/FVC	104±10	104±17	102±3	0.169	0.917
FEF25	85±21	92±14	93±13	2.973	0.035
FEF50	80±22	96±18	88±11	5.649	0.001
FEF75	76±29	95±26	86±17	3.400	0.021
CVA – cough-variant asthma; UACS – upper-airway cough syndrome; PIC – post-infection cough; FEV1 – forced expiratory volume in 1 s; FVC – forced vital capacity; FEF25, 50, 75 – 25%, 50%, 75% forced expiratory flow.

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Fractional Exhaled Nitric Oxide (FeNO) Integrating Airway Hyperresponsiveness (AHR) Examination Promotes Etiologic Diagnosis and Treatment for Children with Chronic Cough

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