22 February 2021 : Clinical Research
Fractional Exhaled Nitric Oxide (FeNO) Integrating Airway Hyperresponsiveness (AHR) Examination Promotes Etiologic Diagnosis and Treatment for Children with Chronic Cough
Haiyan Zhu1BCDEF, Chuangli Hao2BCDE, Xingmei Yu2BCDF, Rongrong Zhang1BCD, Wendi Zhou1BCF, Xingzhen Sun1BCF, Yufang Yuan1BCF, Zhaofang Tian1ABDEG*DOI: 10.12659/MSM.928502
Med Sci Monit 2021; 27:e928502
Table 3 Comparison of the levels of FeNO and other parameters before and after treatment for different etiologies of chronic cough (χ±s).
| Parameters | Before treatment | After treatment | P | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CVA group (n=45) | UACS group (n=53) | PIC group (n=20) | CVA group (n=45) | UACS group (n=53) | PIC group (n=20) | CVA | UACS | PIC | |
| FeNO | 35±14 | 17±8 | 19±8 | 20±7 | 16±6 | 18±6 | 0.001 | 0.374 | 0.412 |
| EOS in sputum (%, median) | 6.5 (6) | 0.5 (1) | 0.5 (1.5) | 2 (3) | 0 (1) | 0 (1) | 0.002 | 0.510 | 0.356 |
| Cough symptom score | 3.5±0.7 | 3.2±0.7 | 3.2±1.0 | 1.5±0.8 | 1.8±0.8 | 1.0±0.9 | 0.000 | 0.000 | 0.000 |
| AHR cases (n) | 45 | 17 | 14 | 45 | 6 | 2 | – | – | – |
| PD20-FEV1 (mg) | 0.48±0.28 | 1.77±0.64 | 1.17±0.75 | 0.61±0.21 | 2.18±0.43 | 2.07±0.44 | 0.046 | 0.003 | 0.001 |
| CVA – cough-variant asthma; UACS – upper-airway cough syndrome; PIC – post-infection cough; FeNO – fractional exhaled nitric oxide; EOS – eosinophils; AHR – airway hyperresponsiveness; PD20-FEV – decrease of 20% in forced expiratory volume in 1 s. | |||||||||