14 December 2020 : Database Analysis
Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Cytokine Pathways Involved in COVID-19 After Rhinovirus Infection in Asthma Patients
Wenjuan Dai1AC, Dawei Cao1BC, Wei Zhang1BF, Yangyang Wei1BD, Daqing Ding2D, Bei Li2C, Yan Gao2D, Lixuan Zhao2C, Yi Jiang1B, Xiaomei Kong1AEG*DOI: 10.12659/MSM.928861
Med Sci Monit 2020; 26:e928861
Table 1 415 DEGs in the intersection of FVA and FVC.
| DEGs | Genes |
|---|---|
| Upregulated | IRF7, MX2, CMPK2, TRIM25, OAS3, IFIT5, DDX60L, RSAD2, MX1, IFI16, ADAR, USP18, STAT1, PNPT1, TRIM14, OAS1, OAS2, XAF1, IFIT1, DHX58, DDX58, CMTR1, RTP4, PARP12, SP100, EPSTI1, IFIT2, PARP9, IFI35, HERC6, LAMP3, UBE2L6, SAMD9L, PLSCR1, HERC5, OASL, IFIT3, C19orf66, IFI44, TRANK1, SP110, HSH2D, DTX3L, ISG15, IFIH1, ZC3HAV1, PARP10, TRIM21, DDX60, PARP14, IFITM1, NMI, SLC25A28, ISG20, ETV7, STAT2, NLRC5, TRIM5, MYD88, TDRD7, SMCHD1, XRN1, TRIM22, PHF11, SAMD9, GTPBP2, RNF213, NT5C3A, LAP3, ZCCHC2, FAM46A, IFI44L, TREX1, SCO2, GTPBP1, PML, FBXO6, TOR1B, PLEKHA4, UBA7, AIM2, TNFSF10, TAP1, NUB1, GBP4, LMO2, MOV10, APOL6, TAPSAR1, GBP1, SCAMP1-AS1, STARD5, EIF2AK2, N4BP1, BST2, TYMP, IFITM3, IRF9, HELZ2, RNF19B, HLA-E, MOB3C, LGALS9, CNP, SPATS2L, ZNFX1, GMPR, OPTN, CXCL10, C5orf56, RBCK1, APOBEC3G, HDX, CSRNP1, SECTM1, PRKD2, PSMB8, FBXO39, TTC39B, PSMB9, WARS, IRF1, BATF2, TRIM38, LGALS17A, LY6E, IFI6, JAK2, CLEC7A, SAMHD1, SP140L, EXOC3L1, PI4K2B, NUPR1, SIDT1, PCGF5, IFNL3, CASP1, ACSL1, EHD4, CD68, TAP2, SLFN5, TLR3, LOC101927027, TRIB2, LIFR, GRIP2, ACE2, MASTL, BCL2L14, TRAFD1, PRICKLE4, APOL2, BCL3, GBP5, BTC, PIK3AP1, SLC15A3, NFE2L3, ZBP1, ZFYVE26, RASGRP3, TMEM140, ZC3H12A, KIAA1551, CTRL, MLKL, NFKBIA, LYSMD2, MAB21L2, GNB4, C17orf67, GBP1P1, DUOX2, PMAIP1, USP30-AS1, SOD2, CIITA, OGFR, LYPD5, APOBEC3A, IFNL1, AKAP7, ACKR4, TNFAIP3, RBMS2, HESX1, HTR2B, MXD1, IL4I1, BLZF1, DUOXA2, NCOA7, RBM11, HRASLS2, SUSD3, FGD2, CCL5, IFI27, TICAM1, CCDC109B, APOBEC3F, GCH1, IL22RA1, TNFSF13B, C19orf38, IKBKE, IFNL2, CASP10, LRRN2, PPM1K, CD7, APOL3, IRAK2, NFKBIZ, UBQLNL, C21orf91, IL7, HLA-F, CD38, RELB, GCNT4, RHBDF2, CX3CL1, CD83, TNFRSF6B, PPM1J, TAGAP, BTN3A3, TMEM229B, FFAR2, CARD16, SOCS1, STX11, OVOL1, IL19, BIRC3, GLRX, CPNE5, MAFF, CXorf49, CXorf49B, CEACAM1, SEC16B, PRDM1, ADCY4, ATF3, LINC00623, TLR2, IFITM2, NRG2, BBC3, SOCS3, KIAA0226, CXCL11, CXCL9, IL15RA, LAG3, STARD4, IDO1, SOCS2, ICOSLG, C1GALT1, FANCA, KCNQ4, NCF1, C10orf105, AP5B1, TMEM171, GBP2, HK2, BRIP1, RAB43, MUC13, IFI30, NCF1C, SP140, HAPLN3, ARID5A, SLC16A1, CD274, KLHDC7B, CACNA1A, CSF3, MAP2, CCL20, TMEM106A, SERPING1, TNFAIP2, CLCA3P, TNIP3, DLG2, CXCL8, MAPK8IP2, IL17C, PLAUR, NEURL3, PROX1, APOBEC3B, TNF, MB21D1, THEMIS2, FRMD3, HBEGF, BRCA2, DUXAP10, TMEM92, DUSP5, EXOC3L4, APOL4, C11orf82, RIMS2, C15orf48, C2CD4B, NOV, ADAM8, SLFN12, MICB, GBP3, GRIN3A, C1R, LOC102724163, SEMA3D, IL2RG, LOC645638, FGF2, FAM169B, LOC100294362, MT2A, ABCD1, ZNF618, LRRC3, SAA4, CYP21A1P, SLC26A4-AS1, SERPINB9, SERPINB9P1, BATF, LOC388692, TLDC2, IL36G, PRRX2, TGM1, ELOVL7, CXCL3, TNFRSF10A, RTKN2, CCL22, HDAC9, ATP10A, IL6, SBK1, BCL2A1, DOC2B, C2CD4A, C1S, ADM, HCG4B, PTPRH, HCAR3, PDCD1LG2, C8orf4, CXCL2, STS, RET, NOS2, SLC26A4, SLCO4A1, SELL, NTNG2, HLA-J, RND1, CFB, XDH, MMP13, TRIM31, SAA2, SPRR2A, PTGS2, MTNR1A, AKAP2, ACHE, DEFB4A, ICAM1, EREG, SPRR2F, CH25H, IL1RN, NEXN, CSF1, HSPA6, LOC554223, APOL1, SLAMF7, LIF, MEF2C, SSC5D, TGM2, ZDHHC14, CXCL13, ERAP2, ANGPTL4, SH2D1B, THSD1, PLA2G4E |
| Downregulated | C20orf195, FAM13C, HPX, INHBB, GPATCH11, PTGFR, PRR18, SLC16A14, SLC47A2 |