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14 December 2020: Database Analysis

Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Cytokine Pathways Involved in COVID-19 After Rhinovirus Infection in Asthma Patients

Wenjuan Dai 1AC* , Dawei Cao 1BC* , Wei Zhang 1BF , Yangyang Wei 1BD , Daqing Ding 2D , Bei Li 2C , Yan Gao 2D , Lixuan Zhao 2C , Yi Jiang 1B , Xiaomei Kong 1AEG*

DOI: 10.12659/MSM.928861

Med Sci Monit 2020; 26:e928861

Table 2 GO functional annotation for the most significantly related targets of 415 DEGs.

GO IDGO TermCountP-value
GO: 0009615Response to virus759.27E-60
GO: 0051607Defense response to virus671.20E-59
GO: 0034341Response to interferon-gamma515.09E-43
GO: 0060337Type I interferon signaling pathway381.25E-40
GO: 0071357Cellular response to type i interferon381.25E-40
GO: 0034340Response to type i interferon388.46E-40
GO: 0071346Cellular response to interferon-gamma451.81E-37
GO: 0048525Negative regulation of viral process332.80E-32
GO: 0060333Interferon-gamma-mediated signaling pathway323.39E-32
GO: 1903901Negative regulation of viral life cycle318.43E-32
GO: 0005125Cytokine activity291.03E-15
GO: 0048018Receptor ligand activity391.62E-13
GO: 0005126Cytokine receptor binding299.81E-13
GO: 0042379Chemokine receptor binding135.95E-10
GO: 0008009Chemokine activity112.92E-09
GO: 0045236CXCR chemokine receptor binding62.79E-08
GO: 0003725Double-stranded RNA binding123.25E-08
GO: 0016814Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines74.39E-06
GO: 0042056Chemoattractant activity79.61E-06
GO: 0048020CCR chemokine receptor binding72.25E-05

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750