14 December 2020: Database Analysis
Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Cytokine Pathways Involved in COVID-19 After Rhinovirus Infection in Asthma Patients
Wenjuan Dai 1AC* , Dawei Cao 1BC* , Wei Zhang 1BF , Yangyang Wei 1BD , Daqing Ding 2D , Bei Li 2C , Yan Gao 2D , Lixuan Zhao 2C , Yi Jiang 1B , Xiaomei Kong 1AEG*DOI: 10.12659/MSM.928861
Med Sci Monit 2020; 26:e928861
Table 2 GO functional annotation for the most significantly related targets of 415 DEGs.
| GO ID | GO Term | Count | P-value |
|---|---|---|---|
| GO: 0009615 | Response to virus | 75 | 9.27E-60 |
| GO: 0051607 | Defense response to virus | 67 | 1.20E-59 |
| GO: 0034341 | Response to interferon-gamma | 51 | 5.09E-43 |
| GO: 0060337 | Type I interferon signaling pathway | 38 | 1.25E-40 |
| GO: 0071357 | Cellular response to type i interferon | 38 | 1.25E-40 |
| GO: 0034340 | Response to type i interferon | 38 | 8.46E-40 |
| GO: 0071346 | Cellular response to interferon-gamma | 45 | 1.81E-37 |
| GO: 0048525 | Negative regulation of viral process | 33 | 2.80E-32 |
| GO: 0060333 | Interferon-gamma-mediated signaling pathway | 32 | 3.39E-32 |
| GO: 1903901 | Negative regulation of viral life cycle | 31 | 8.43E-32 |
| GO: 0005125 | Cytokine activity | 29 | 1.03E-15 |
| GO: 0048018 | Receptor ligand activity | 39 | 1.62E-13 |
| GO: 0005126 | Cytokine receptor binding | 29 | 9.81E-13 |
| GO: 0042379 | Chemokine receptor binding | 13 | 5.95E-10 |
| GO: 0008009 | Chemokine activity | 11 | 2.92E-09 |
| GO: 0045236 | CXCR chemokine receptor binding | 6 | 2.79E-08 |
| GO: 0003725 | Double-stranded RNA binding | 12 | 3.25E-08 |
| GO: 0016814 | Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | 7 | 4.39E-06 |
| GO: 0042056 | Chemoattractant activity | 7 | 9.61E-06 |
| GO: 0048020 | CCR chemokine receptor binding | 7 | 2.25E-05 |