14 December 2020: Database Analysis
Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Cytokine Pathways Involved in COVID-19 After Rhinovirus Infection in Asthma Patients
Wenjuan Dai 1AC* , Dawei Cao 1BC* , Wei Zhang 1BF , Yangyang Wei 1BD , Daqing Ding 2D , Bei Li 2C , Yan Gao 2D , Lixuan Zhao 2C , Yi Jiang 1B , Xiaomei Kong 1AEG*DOI: 10.12659/MSM.928861
Med Sci Monit 2020; 26:e928861
Table 3 KEGG functional annotation for 415 DEGs.
| KEGG ID | KEGG Term | Count | P-value |
|---|---|---|---|
| hsa05164 | Influenza A | 33 | 4.44E-20 |
| hsa04621 | NOD-like receptor signaling pathway | 30 | 2.20E-16 |
| hsa04060 | Cytokine-cytokine receptor interaction | 34 | 1.28E-13 |
| hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 20 | 7.62E-13 |
| hsa04668 | TNF signaling pathway | 20 | 7.04E-12 |
| hsa05162 | Measles | 22 | 7.43E-12 |
| hsa05169 | Epstein-Barr virus infection | 24 | 3.95E-10 |
| hsa05160 | Hepatitis C | 20 | 3.30E-09 |
| hsa04064 | NF-kappa B signaling pathway | 16 | 9.32E-09 |
| hsa04657 | IL-17 signaling pathway | 15 | 1.65E-08 |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 21 | 1.77E-08 |
| hsa04630 | JAK-STAT signaling pathway | 19 | 3.65E-08 |
| hsa04623 | Cytosolic DNA-sensing pathway | 12 | 6.12E-08 |
| hsa04620 | Toll-like receptor signaling pathway | 15 | 6.73E-08 |
| hsa04622 | RIG-I-like receptor signaling pathway | 12 | 2.08E-07 |
| hsa04625 | C-type lectin receptor signaling pathway | 14 | 4.49E-07 |
| hsa04217 | Necroptosis | 17 | 7.52E-07 |
| hsa05134 | Legionellosis | 10 | 1.77E-06 |
| hsa04062 | Chemokine signaling pathway | 18 | 1.94E-06 |
| hsa05133 | Pertussis | 11 | 3.86E-06 |
| hsa05161 | Hepatitis B | 16 | 4.60E-06 |
| hsa05168 | Herpes simplex virus 1 infection | 29 | 2.77E-05 |
| hsa05323 | Rheumatoid arthritis | 11 | 2.78E-05 |
| hsa05170 | Human immunodeficiency virus 1 infection | 16 | 0.000129 |
| hsa05145 | Toxoplasmosis | 11 | 0.000155 |
| hsa05140 | Leishmaniasis | 9 | 0.000166 |
| hsa05144 | Malaria | 7 | 0.000289 |
| hsa05143 | African trypanosomiasis | 6 | 0.00035 |
| hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 9 | 0.000498 |
| hsa04612 | Antigen processing and presentation | 8 | 0.000928 |
| hsa04930 | Type II diabetes mellitus | 6 | 0.00116 |
| hsa05142 | Chagas disease (American trypanosomiasis) | 9 | 0.001339 |