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14 December 2020: Database Analysis

Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Cytokine Pathways Involved in COVID-19 After Rhinovirus Infection in Asthma Patients

Wenjuan Dai 1AC* , Dawei Cao 1BC* , Wei Zhang 1BF , Yangyang Wei 1BD , Daqing Ding 2D , Bei Li 2C , Yan Gao 2D , Lixuan Zhao 2C , Yi Jiang 1B , Xiaomei Kong 1AEG*

DOI: 10.12659/MSM.928861

Med Sci Monit 2020; 26:e928861

Table 3 KEGG functional annotation for 415 DEGs.

KEGG IDKEGG TermCountP-value
hsa05164Influenza A334.44E-20
hsa04621NOD-like receptor signaling pathway302.20E-16
hsa04060Cytokine-cytokine receptor interaction341.28E-13
hsa04061Viral protein interaction with cytokine and cytokine receptor207.62E-13
hsa04668TNF signaling pathway207.04E-12
hsa05169Epstein-Barr virus infection243.95E-10
hsa05160Hepatitis C203.30E-09
hsa04064NF-kappa B signaling pathway169.32E-09
hsa04657IL-17 signaling pathway151.65E-08
hsa05167Kaposi sarcoma-associated herpesvirus infection211.77E-08
hsa04630JAK-STAT signaling pathway193.65E-08
hsa04623Cytosolic DNA-sensing pathway126.12E-08
hsa04620Toll-like receptor signaling pathway156.73E-08
hsa04622RIG-I-like receptor signaling pathway122.08E-07
hsa04625C-type lectin receptor signaling pathway144.49E-07
hsa04062Chemokine signaling pathway181.94E-06
hsa05161Hepatitis B164.60E-06
hsa05168Herpes simplex virus 1 infection292.77E-05
hsa05323Rheumatoid arthritis112.78E-05
hsa05170Human immunodeficiency virus 1 infection160.000129
hsa05143African trypanosomiasis60.00035
hsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer90.000498
hsa04612Antigen processing and presentation80.000928
hsa04930Type II diabetes mellitus60.00116
hsa05142Chagas disease (American trypanosomiasis)90.001339

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750