01 March 2021 : Database Analysis
Comparison of Prognostic Value Among 4 Risk Scores in Patients with Acute Coronary Syndrome: Findings from the Improving Care for Cardiovascular Disease in China-ACS (CCC-ACS) Project
Jieleng Huang12BCEF, Xuebiao Wei23CD, Yu Wang2BE, Mei Jiang2BC, Yingwen Lin2BC, Zedazhong Su2BC, Peng Ran2B, Yingling Zhou2G, Jiyan Chen2AG*, Danqing Yu12AGDOI: 10.12659/MSM.928863
Med Sci Monit 2021; 27:e928863
Table 2 ROC Comparison for death, MACEs, bleeding, according to the C-ACS, ACEF, AGEF, and GRACE risk score.
| NST-ACS | STEMI | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Comparison (A vs B) | AUC-A% | AUC-B% | ΔAUC% | P value | AUC-A% | AUC-B% | ΔAUC% | P value | |
| Death | C-ACS vs ACEF | 76.6 | 82.7 | 6.1 (2.0 to 10.0) | 0.003 | 76.7 | 82.7 | 6.0 (3.4 to 8.7) | <0.001 |
| C-ACS vs AGEF | 76.6 | 83.2 | 6.6 (2.8 to 10.4) | <0.001 | 76.7 | 84.5 | 7.8 (5.4 to10.2) | <0.001 | |
| C-ACS vs GRACE | 76.6 | 85.3 | 8.7 (5.4 to 12.0) | <0.001 | 76.7 | 81.9 | 5.2 (3.5 to 7.1) | <0.001 | |
| ACEF vs AGEF | 82.7 | 83.2 | 0.5 (−1.3 to 2.4) | 0.559 | 82.7 | 84.5 | 1.8 (0.3 to 3.1) | 0.014 | |
| ACEF vs GRACE | 82.7 | 85.3 | 2.6 (−0.3 to 5.7) | 0.082 | 82.7 | 81.9 | 0.8 (−1.5 to 3.1) | 0.486 | |
| AGEF vs GRACE | 83.2 | 85.3 | 2.1 (−0.7 to 4.9) | 0.140 | 84.5 | 81.9 | 2.6 (0.6 to 4.5) | 0.012 | |
| MACEs | C-ACS vs ACEF | 75.1 | 77.7 | 2.6 (1.2 to 4.0) | <0.001 | 71.1 | 71.9 | 0.8 (−0.4 to 1.8) | 0.190 |
| C-ACS vs AGEF | 75.1 | 77.6 | 2.5 (1.1 to 3.9) | <0.001 | 71.1 | 72.1 | 1.0 (−0.2 to 2.0) | 0.094 | |
| C-ACS vs GRACE | 75.1 | 79.7 | 4.6 (3.5 to 5.6) | <0.001 | 71.1 | 73.0 | 1.9 (1.1 to 2.6) | <0.001 | |
| ACEF vs AGEF | 77.7 | 77.6 | 0.1 (−0.5 to 0.7) | 0.669 | 71.9 | 72.1 | 0.2 (−0.2 to 0.6) | 0.374 | |
| ACEF vs GRACE | 77.7 | 79.7 | 2.0 (0.7 to 3.1) | 0.002 | 71.9 | 73.0 | 1.1 (0.2 to 2.0) | 0.022 | |
| AGEF vs GRACE | 77.6 | 79.7 | 2.1 (0.9 to 3.2) | <0.001 | 72.1 | 73.0 | 0.9 (0.0 to 1.8) | 0.049 | |
| Bleeding | C-ACS vs ACEF | 57.8 | 64.1 | 6.3 (2.9 to 9.8) | <0.001 | 58.0 | 57.6 | 0.4 (−1.7 to 2.4) | 0.744 |
| C-ACS vs AGEF | 57.8 | 65.0 | 7.2 (3.9 to 10.6) | <0.001 | 58.0 | 58.2 | 0.2 (−1.8 to 2.3) | 0.828 | |
| C-ACS vs GRACE | 57.8 | 64.6 | 6.8 (4.1 to 9.6) | <0.001 | 58.0 | 59.4 | 1.4 (−0.1 to 3.0) | 0.062 | |
| ACEF vs AGEF | 64.1 | 65.0 | 0.9 (−0.5 to 2.3) | 0.192 | 57.6 | 58.2 | 0.6 (−0.2 to 1.4) | 0.149 | |
| ACEF vs GRACE | 64.1 | 64.6 | 0.5 (−2.3 to 3.3) | 0.724 | 57.6 | 59.4 | 1.8 (0.1 to 3.5) | 0.038 | |
| AGEF vs GRACE | 65.0 | 64.6 | 0.4 (−2.4 to 3.2) | 0.765 | 58.2 | 59.4 | 1.2 (−0.5 to 2.9) | 0.155 | |
| ROC – receiver operating characteristics; NSTE-ACS – non-ST segment-elevation acute coronary syndrome; STEMI – ST segment elevation myocardial infarction; C-ACS – Canada Acute Coronary Syndrome risk score; ACEF – age, creatinine and ejection fraction risk score; AGEF – modified version of ACEF risk score; GRACE – Global Registry for Acute Coronary Events risk scores; MACE – major adverse clinical events. | |||||||||