01 March 2021 : Database Analysis
Comparison of Prognostic Value Among 4 Risk Scores in Patients with Acute Coronary Syndrome: Findings from the Improving Care for Cardiovascular Disease in China-ACS (CCC-ACS) Project
Jieleng Huang12BCEF, Xuebiao Wei23CD, Yu Wang2BE, Mei Jiang2BC, Yingwen Lin2BC, Zedazhong Su2BC, Peng Ran2B, Yingling Zhou2G, Jiyan Chen2AG*, Danqing Yu12AGDOI: 10.12659/MSM.928863
Med Sci Monit 2021; 27:e928863
Table 3 Subgroup analysis of ROC curve comparison for in-hospital adverse events.
| Comparison (A vs B) | PCI | Non-PCI | |||||||
|---|---|---|---|---|---|---|---|---|---|
| AUC-A% | AUC-B% | ΔAUC% | P value | AUC-A% | AUC-B% | ΔAUC% | P value | ||
| Death | C-ACS vs ACEF | 75.9 | 81.1 | 5.2(1.8 to 8.7) | 0.003 | 72.8 | 79.7 | 6.9(3.9 to 9.9) | <0.001 |
| C-ACS vs AGEF | 75.9 | 82.7 | 6.8(3.8 to 9.9) | <0.001 | 72.8 | 80.5 | 7.7(4.7 to 10.6) | <0.001 | |
| C-ACS vs GRACE | 75.9 | 83.4 | 7.5(5.1 to 9.9) | <0.001 | 72.8 | 79.5 | 6.7(4.6 to 8.8) | <0.001 | |
| ACEF vs AGEF | 81.1 | 82.7 | 1.6(−0.1 to 3.3) | 0.072 | 79.7 | 80.5 | 0.8(−0.8 to 2.4) | 0.354 | |
| ACEF vs GRACE | 81.1 | 83.4 | 2.3(−0.7 to 5.2) | 0.133 | 79.7 | 79.5 | 0.2(−2.3 to 2.6) | 0.883 | |
| AGEF vs GRACE | 82.7 | 83.4 | 0.7(−1.9 to 3.2) | 0.608 | 80.5 | 79.5 | 0.9(−1.2 to 3.2) | 0.404 | |
| MACEs | C-ACS vs ACEF | 70.3 | 71.2 | 0.9(−0.3 to 2.1) | 0.157 | 72.8 | 74.8 | 2.0(0.7 to 3.3) | 0.003 |
| C-ACS AGEF | 70.3 | 71.3 | 1.0(−0.3 to 2.1) | 0.132 | 72.8 | 74.6 | 1.8(0.5 to 3.1) | 0.007 | |
| C-ACS vs GRACE | 70.3 | 73.4 | 3.1(2.3 to 3.9) | <0.001 | 72.8 | 76.4 | 3.6(2.6 to 4.5) | < 0.001 | |
| ACEF vs AGEF | 71.2 | 71.3 | 0.1(−0.4 to 0.5) | 0.858 | 74.8 | 74.6 | 0.2(−0.4 to 0.8) | 0.516 | |
| ACEF vs GRACE | 71.2 | 73.4 | 2.2(1.2 to 3.3) | <0.001 | 74.8 | 76.4 | 1.6(0.4 to 2.7) | 0.009 | |
| AGEF vs GRACE | 71.3 | 73.4 | 2.1(1.2 to 3.2) | <0.001 | 74.6 | 76.4 | 1.8(0.6 to 2.9) | 0.002 | |
| Bleeding | C-ACS vs ACEF | 57.7 | 59.1 | 1.4(−0.8 to 3.5) | 0.234 | 57.2 | 58.9 | 1.7(−1.7 to 5.1) | 0.322 |
| C-ACS vs AGEF | 57.7 | 59.2 | 1.5(−0.6 to 3.6) | 0.168 | 57.2 | 60.6 | 3.4(0.1 to 6.6) | 0.045 | |
| C-ACS vs GRACE | 57.7 | 60.6 | 2.9(1.2 to 4.4) | <0.001 | 57.2 | 62.8 | 5.6(3.3 to 8.0) | <0.001 | |
| ACEF vs AGEF | 59.1 | 59.2 | 0.1(−0.6 to 0.9) | 0.628 | 58.9 | 60.6 | 1.7(0.0 to 3.3) | 0.048 | |
| ACEF vs GRACE | 59.1 | 60.6 | 1.5(−0.2 to 3.3) | 0.090 | 58.9 | 62.8 | 3.9(1.1 to 6.7) | 0.005 | |
| AGEF vs GRACE | 59.2 | 60.6 | 1.4(−0.4 to 3.1) | 0.135 | 60.6 | 62.8 | 2.2(−0.4 to 5.0) | 0.101 | |
| ROC – receiver operating characteristics; PCI – percutaneous transluminal coronary intervention; C-ACS – Canada Acute Coronary Syndrome risk score; ACEF – age, creatinine and ejection fraction risk score; AGEF – modified version of ACEF risk score; GRACE – Global Registry for Acute Coronary Events risk scores; MACE – major adverse clinical events. | |||||||||