03 February 2021 : Clinical Research
U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study
Hao You1ABCE, Kegong Chen2BCE, Pengfei Han3C, ChaoFu Yue4B, Xia Zhao5ADEG*DOI: 10.12659/MSM.928937
Med Sci Monit 2021; 27:e928937
Supplementary Table 2 Stratification analysis by estimated glomerular filtration rate.
Uric acid, mg/dl | Non-CKD (n=12,643) | p Value | CKD* (n=2,516) | p Value |
---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||
All-cause mortality | ||||
≤3.5 | 1.42 (1.02–1.98) | 0.036 | 1.57 (0.77–3.21) | 0.211 |
3.5–5.0 | 1.09 (0.93–1.27) | 0.311 | 1.10 (0.86–1.41) | 0.435 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 0.99 (0.84–1.18) | 0.948 | 1.31 (1.06–1.62) | 0.013 |
>7.5 | 1.37 (1.09–1.71) | 0.007 | 1.52 (1.21–1.90) | 0.000 |
CVD mortality* | ||||
≤3.5 | 1.73 (0.94–3.21) | 0.078 | 4.95 (1.29–19.01) | 0.021 |
3.5–5.0 | 1.25 (0.81–1.93) | 0.308 | 1.32 (0.70–2.49) | 0.383 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 0.94 (0.65–1.35) | 0.731 | 1.69 (0.97–2.94) | 0.063 |
>7.5 | 1.79 (1.06–3.00) | 0.029 | 1.43 (0.80–2.58) | 0.226 |
Heart-related mortality | ||||
≤3.5 | 1.31 (0.67–2.55) | 0.421 | 1.49 (0.15–14.55) | 0.727 |
3.5–5.0 | 1.19 (0.78–1.80) | 0.420 | 1.12 (0.63–1.99) | 0.706 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 1.05 (0.78–1.43) | 0.731 | 1.43 (0.86–2.36) | 0.166 |
>7.5 | 1.75 (1.11–2.77) | 0.017 | 1.57 (0.93–2.67) | 0.092 |
Stroke mortality* | ||||
≤3.5 | 4.04 (1.32–12.44) | 0.016 | 13.12 (2.33–73.86) | 0.004 |
3.5–5.0 | 1.22 (0.55–2.70) | 0.625 | 1.04 (0.26–4.16) | 0.958 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 0.93 (0.37–2.32) | 0.878 | 2.23 (0.84–5.92) | 0.107 |
>7.5 | 1.18 (0.37–3.77) | 0.775 | 1.50 (0.43–5.28) | 0.518 |
* CKD was defined as estimated glomerular filtration rate less than 60 mL/min/1.73 m; ** estimated in NHANES 1999–2006. Hazard ratio (95% confidence interval) was estimated via weighted cox regression analysis after adjustment for age (years, continuous), sex (female or male), race/ethnicity (non-Hispanic white, black, Hispanic-Mexican, or other), poverty to income ratio ( |